The Ran-binding protein-2 (RanBP2) is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. Kyoung-in Cho, Haiqing Yi, Ria Desai, Arthur R. Hand, Arthur L. Haas and Paulo A. Ferreira* 1, 4 Department of Ophthalmology, Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710 Departments of Craniofacia...

While the application of corporate social responsibility (CSR) into business for sustainable development is becoming a popular trend in developed countries, this issue is considered relatively new to developing countries, particularly in Vietnam. In addition, CSR studies conducted in Vietnam remain very scarce. Most of the enterprise do not have adequate understandings of CSR’s aspects, but the...

The stepping behavior of single kinesin-1 motor proteins has been studied in great detail. However, in cells, these motors often do not work alone but rather function in small groups when they transport cellular cargo. Until now, the cooperative interactions between motors in such groups were poorly understood. A fundamental question is whether two or more motors that move the same cargo step i...

We report on a young boy with neurodevelopmental disorder who is carrier of novel frameshift mutation in gene MAP7D3 (MAP7 domain containing 3) Xq26.3. The protein encoded by this belongs to the MAP7 (microtubuleassociated 7) family that proposed regulate kinesin-1 (KIF5B)-dependent intracellular transport, acting as Microtubule (MT)-tethered recruitment factors and activators kinesin [1-3]. An...

Recently, rearranged during transfection (RET) fusions have been identified in approximately 1% of non-small cell lung cancer (NSCLC). To know the prevalence of RET fusion genes in Korean NSCLCs, we examined the RET fusion genes in 156 surgically resected NSCLCs using a reverse transcriptase polymerase chain reaction. Two KIF5B-RET fusions and one CCDC6-RET fusion were identified. All three pat...