Kinetic modeling of metabolic pathways has important applications in metabolic engineering, but significant challenges still remain. The difficulties faced vary from finding best-fit parameters in a highly multidimensional search space to incomplete parameter identifiability. To meet some of these challenges, an ensemble modeling method is developed for characterizing a subset of kinetic parame...

in this paper, we review novel techniques in the emerging field of spatiotemporal 4d pet imaging. we will discuss existing limitations in conventional dynamic pet imaging which involves independent reconstruction of dynamic pet datasets. various approaches that seek to attempt some or all of these limitations are reviewed in this work, including techniques that utilize iterative temporal smooth...

It is commonly the case in biochemical modelling that we have knowledge of the qualitative 'structure' of a model and some measurements of the time series of the variables of interest (concentrations and fluxes), but little or no knowledge of the model's parameters. This is, then, a system identification problem, that is commonly addressed by running a model with estimated parameters and assess...

Background: Translating a known metabolic network into a dynamic model requires reasonable guesses of all enzyme parameters. In Bayesian parameter estimation, model parameters are described by a posterior probability distribution, which scores the potential parameter sets, showing how well each of them agrees with the data and with the prior assumptions made. Results: We compute posterior distr...

In this study, nano-TiO2 was employed for the adsorption of chloroform from aqueous solution in batch equilibrium experiments to investigate its adsorption properties. The effects of pH, initial chloroform concentration and nano-TiO2 dosage were also investigated. Optimal conditions for chloroform removal by nano-TiO2 have been then identified. Results of equilibrium experiments showed that the...

Combined kinetic analysis has been applied for the first time to the thermal degradation of polymeric materials. The combined kinetic analysis allows the determination of the kinetic parameter from the simultaneous analysis of a set of experimental curves recorded under any thermal schedule. Besides, the method does not make any assumption about the kinetic model or activation energy and allows...

We consider two approaches to modelling of cell metabolism of 6-mercaptopurine, which is one of the important chemotherapy drugs used for treating of acute lymphocytic leukemia: kinetic ordinary differential equations and random Boolean networks, and analyse their interplay with respect to taking into account ATP concentration as a key parameter of switching between different pathways. It is sh...

1. There are now two categories of particles, active (moving and interacting kinetically) and passive (remaining still and inactive). An active particle holds a recipe of the swarm (i.e., a list of kinetic parameter sets) in it (Fig. 1(a)). 2. A recipe is transmitted from an active particle to a passive particle when they collide, making the latter active (Fig. 1(b)). 3. The activated particle ...

In this study, nano-TiO2 was employed for the adsorption of chloroform from aqueous solution in batch equilibrium experiments to investigate its adsorption properties. The effects of pH, initial chloroform concentration and nano-TiO2 dosage were also investigated. Optimal conditions for chloroform removal by nano-TiO2 have been then identified. Results of equilibrium experiments showed that the...