Increasing evidence shows that liver tumor-initiating cells (T-ICs) closely associated with the progression, metastasis, recurrence and chemo-resistance of hepatocellular carcinoma (HCC). However, underlying mechanism for propagation T-ICs remains unclear. Here we show miR-361-3p is upregulated in T-ICs. Knockdown impairs self-renewal tumorigenicity Conversely, forced expression enhances Mechan...

Hepatocellular carcinoma (HCC) is the most common cancer of digestive system. Recently, transmembrane proteins (TMEMs) have been extensively studied in different types malignant tumors. However, influence TMEM206 hepatocellular unclear. The UALCAN database was used to investigate expression mRNA liver tissues and Human Protein Atlas (THPA) study HCC tissues. measured normal HL-7702 cells HepG2,...

Trehalose is the nonreducing disaccharide of glucose, evolutionarily conserved in invertebrates. The living skin equivalent (LSE) an organotypic coculture containing keratinocytes cultivated on fibroblast-populated dermal substitutes. We demonstrated that human primary fibroblasts treated with highly concentrated trehalose promote significantly extensive spread epidermal layer LSE without any d...

To explore the correlation of traits linked to thermotolerance, we compared three thermal endpoints (knockdown temperature and two critical thermal maxima) among replicate populations of Drosophila melanogaster selected for high, or low, knockdown temperature. The high knockdown flies maintain normal posture and locomotor ability within a knockdown column at temperatures >or=40 degrees C, where...

Background: Long noncoding RNAs played critical roles in glioblastoma development. Objectives: This study aimed to examine the impacts of lncRNA DLK1-35 on cells and mice. Methods: Methyl Thiazolyl Tetrazolium (MTT) was applied for examining viabilities U87 U251 cells, as well IC50 values temozolomide (TMZ). LncRNA expressions were detected using RT-qPCR. Proliferation apoptosis TMZ-resistant (...