Some 1,5-diaryl-3-ethoxycarbonyl-2-methylpyrrole derivatives were obtained by reacting 1-aryl-3-ethoxycarbonylpent-1,4-diones and a suitable aniline derivative or sulfanilamide under Paal-Knorr pyrrole synthesis conditions. The cytotoxicity of the compounds was tested and all compounds, except for compound 2 h, showed a time-dependent increase in cytotoxic activity. Analgesic activities of the ...

Through the case of a particular organization devoted to technological research and development, this paper investigates how values of the ‘new’ operate in what Appadurai (1986) has characterized as the social life of objects. Drawing on previous scholarship in anthropology and science and technology studies, I adopt the trope of the ‘affiliative object’ to describe the relational dynamics of a...

Alkyl β-d-xylopyranosides are highly surface active, biodegradable surfactants that can be prepared from hemicelluloses and are of interest for use as pharmaceuticals, detergents, agrochemicals, and personal care products. To gain further insights into their structure-property and structure-activity relationships, the present study synthesized a series of hydrocarbon (-C(6)H(13) to -C(16)H(33))...

Karen Knorr's sumptuous composed `tableaux' photographs are the subject of this book, accompanied by three essays, the most useful of which takes the form of a conversation between the photographer and Rebecca Comay. They discuss aspects of Knorr's work, notably her interest in the preservation of cultural heritage and the ways in which the animal is separated from the human in museums. Thus na...

2-(methylthio)-1,4-diaryl-2-butene-1,4-dione (3) are prepared from readily available aryl methyl ketones in the presence of copper(II) oxide, iodine, and dimethyl sulfoxide. The success of the cross-coupling reaction of 4-chloroacetophenone with 2-acetylthiophene confirms a proposed self-sorting tandem reaction mechanism. Both Z- and E-isomers of compound 3 are readily converted into the corres...

Knowledge discovery in databases, commonly referred to as data mining, has attracted enormous research efforts from different domains such as database, statistics, artificial intelligence, data visualization, etc, in the past decade. Most of the research work in data mining such as clustering, association rules mining and classification focus on discovering the “large patterns” from databases (...

One of the greatest contributions of Science and Technology Studies (STS), in the last 30 years, has been to show that the contours of science/technology and society are inextricably interwoven (Bloor [1976] 1991, Latour & Woolgar [1979] 1986; Knorr Cetina 1981; Shapin & Schaffer 1985; Latour 1987; Haraway 1991). These studies have highlighted that techno-scientific developments are path-depend...

For many applications in knowledge discovery in databases finding outliers, rare events, is of importance. Outliers are observations, which deviate significantly from the rest of the data, so that it seems they are generated by another process (Hawkins, 1980). Such outlier objects often contain information about an untypical behavior of the system. However, outliers bias the results of many dat...