Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's Disease (AD). In this study, methanol, dichloromethane and aqueous crude extracts from 80 Traditional Chinese Medical (TCM) plants were tested for their in vitro anti-acetylcholinesterase activity based on Ellman's colorimetric assay. All three extracts of Berberis ...

GYF domains are conserved eukaryotic adaptor domains that recognize proline-rich sequences. Although the structure and function of the prototypic GYF domain from the human CD2BP2 protein have been characterized in detail, very little is known about GYF domains from other proteins and species. Here we describe the binding properties of four GYF domains of various origins. Phage display in combin...

Recent advances in robotics and computer vision have enabled the implementation of sophisticated vision-based relative navigation algorithms for robotic spacecraft using a single calibrated monocular camera. These techniques, initially developed for ground robots, show great promise for robotic spacecraft applications. However, several challenges still exist, which hinder the direct use of thes...

Cross-language speech recognition often assumes a certain amount of knowledge about the target language. However, there are hundreds of languages where not even the phoneme inventory is known. In the work reported here, phone recognisers are evaluated on a cross-language task with minimum target knowledge. A phonetic distance measure is introduced for the evaluation, allowing a distance to be c...

In this study, a novel discrimination method for known and unknown target using High-Resolution Range Profile (HRRP), namely log-likelihood ratio score method, is proposed. The aim of this method is to minimize the error probability of discrimination by constructing the unknown target model when the data of unknown target is lack. The Gaussian Mixture Model (GMM) is introduced to model the stat...