Both human epidermal growth factor receptor 2 (HER-2/neu) and VEGF overexpression correlate with aggressive phenotypes and decreased survival among breast cancer patients. Concordantly, the combination of trastuzumab (anti-HER2) with bevacizumab (anti-VEGF) has shown promising results in preclinical xenograft studies and in clinical trials. However, despite the known antiangiogenic mechanism of...

Zeranol (alpha-zearalanol) is a metabolite of the mycoestrogen zearalenone, and is used as a growth promoter of livestock due to its strong estrogenic activity. In the present study, we investigated the effects of zeranol on the growth of estrogen receptor (ER)-positive and -negative human breast carcinoma cells in vitro, and the molecules involved. At low concentrations, zeranol accelerated th...

In 19 excised left human lungs, seven of which were emphysema-free, lobar pressure-volume (P-V) characteristics were analysed by fitting to the P-V data an exponential of the form V=A-Be-KPL (where V is the volume at a transpulmonary pressure (PL), A is the theoretical lung volume at infinite PL, B is the difference between A and the intercept of the fitted exponential on the volume axis and K ...

We summarize a book under publication with the above title written by the three present authors, on the theory of Zipf’s law, and more generally of power laws, driven by the mechanism of proportional growth. The preprint is available upon request from the authors. For clarity, consistence of language and conciseness, we discuss the origin and conditions of the validity of Zipf’s law using the t...

Nitrogenase comprises two proteins, each of which has very similar properties when isolated from any of the diazotrophs studied so far. Both exhibit e.p.r. signals in the resting state and during enzyme turnover. The larger one is generally called the MoFe protein, although other names are sometimes used (e.g. dinitrogenase; Hageman & Burris, 1978), and the most active preparations contain 2 Mo...

Breast cancer progression is driven by altered gene expression. We show that the RIN1 gene, which encodes a RAS effector regulating epithelial cell properties, is silenced in breast tumor cell lines compared with cultured human mammary epithelial cells. We also report that RIN1 is often reduced in human breast tumor cells compared with morphologically normal breast glandular cells. At least two...

The information available to modern autonomous systems is often in the form of streams. As the number of sensors and other stream sources increases there is a growing need for incremental reasoning about the incomplete content of sets of streams in order to draw relevant conclusions and react to new situations as quickly as possible. To act rationally, autonomous agents often depend on high lev...

Both human epidermal growth factor receptor 2 (HER-2/neu) and VEGF overexpression correlate with aggressive phenotypes and decreased survival among breast cancer patients. Concordantly, the combination of trastuzumab (anti-HER2) with bevacizumab (anti-VEGF) has shown promising results in preclinical xenograft studies and in clinical trials. However, despite the known antiangiogenic mechanism of...

BACKGROUND Ginsenoside Rp1 (G-Rp1) is a novel ginsenoside derived from ginsenoside Rk1. This compound was reported to have anticancer, anti-platelet, and anti-inflammatory activities. In this study, we examined the molecular target of the antiproliferative and proapoptotic activities of G-Rp1. METHODS To examine the effects of G-Rp1, cell proliferation assays, propidium iodine staining, prote...

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