BACKGROUND AND PURPOSE Babies are frequently exposed to hypoxia and ischemia during the perinatal period as a result of stroke or problems with delivery or respiratory management post delivery. The only U.S. Food and Drug Administration-approved treatment for acute stroke is the administration of tPA. Nonetheless, basic science studies indicate that tPA exhibits both beneficial and deleterious ...

Triphenylamine (TPA)-functionalized magnetic microspheres (Fe(3)O(4)/SiO(2)/TPA) were prepared and applied as solid phase extraction (SPE) adsorbents for the analysis of polycyclic aromatic hydrocarbons (PAHs) in environmental samples in combination with high-performance liquid chromatography (HPLC). The magnetic solid-phase extraction (MSPE) conditions affecting the extraction efficiency were ...

Human monomorphonuclear leukocytes (MMNs) stimulated with 12-O-tetradecanoylphortx)l-13-acetate (TPA) were found to be toxic towards human A549 lung carcinoma cells which have been desensitized against the direct growth-inhibitory effect of TPA. This toxicity was dependent on the TPA concentration and the ratio of MMNs to A549 cells. Using a TPA concentration of 10~7 M and an effectortarget cel...

Thyroid Patient Advocacy-UK (TPA-UK) disagrees with many of the statements made by the Executive Committee of the British Thyroid Association (BTA) on natural desiccated porcine thyroid extract (Armour® Thyroid, USP). TPA-UK are very concerned that the BTA continue to advise that L-thyroxine (T4) replacement remains the treatment of choice despite the amount of evidence contrary to their opinio...

We conducted terephthalic acid (TPA) synthesis from p-xylene in high-temperature liquid water (HTW) at 3008C. The p-xylene concentration at the reaction condition was 0.2 mol L, which is the highest to date in research that achieved at least 80 mol % yields of TPA in HTW. Pure oxygen gas was the oxidant. Increasing the MnBr2 catalyst concentration increased the rate of TPA formation only slight...

Protein kinase C i I'M i activation is often antiapoptotic, although in a few cell types PKC initiates apoptosis by an unknown mechanism. Recent investigations showed that activation of PKCa by 12-0-tetradecanoylphorbol 13-acetate (TPA) induced apoptosis in LNCaP prostate cancer cells. The present studies examine the mechanism of this effect and show that (/<• novo ceramide generation through...

Antimicrobial resistance is a growing global concern in human and veterinary medicine, with an ever-increasing void in the arsenal of clinicians. Novel classes of compounds including carbon monoxoide-releasing molecules (CORMs), for example the light-activated metal complex [Mn(CO)3(tpa-κ3N)]Br, could be used as alternatives/to supplement traditional antibacterials. Avian pathogenic Escherichia...

There has been much recent interest in the role of a calcium-dependent, phospholipid-dependcnt protein kinase (PKC) in regulation of macro phage function and growth. In order to better define the role of PKC in these processes we have developed mutants of the RAW264 macrophagelike cell line that are resistant to the growth-inhibiting effects of 12-0tetradecanoylphorbol-13-acetate (TPA), a poten...

  Background: Thrombolytic therapy is the only approved treatment for acute cerebral ischemia. The hemorrhagic transformation is the greatest complication of this treatment, which may occur after recanalization of occluded artery. The aim of this study was to determine factors associated with clinical improvement and worsening in patients with acute ischemic stroke treated with intravenous th...