Using microspectrofluorimetry and the calcium-sensitive dye fura-2, we examined the effect of excitatory amino acids on [Ca2+]i in single striatal neurons in vitro. N-methyl-D-aspartic acid (NMDA) produced rapid increases in [Ca2+]i. These were blocked by DL-2-amino-5-phosphonovaleric acid (AP5), by Mg2+, by phencyclidine, and by MK801. The block produced by Mg2+ and MK801 could be relieved by ...

Fantozzi, Ivana, Shen Zhang, Oleksandr Platoshyn, Carmelle V. Remillard, Randy T. Cowling, and Jason X.-J. Yuan. Hypoxia increases AP-1 binding activity by enhancing capacitative Ca2 entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 285: L1233–L1245, 2003. First published August 8, 2003; 10.1152/ajplung.00445.2002.—Activating protein (AP)-1 transcription fact...

Imipramine is a tricyclic antidepressant drug that also exhibits antiarrhythmic effects and whose clinical spectrum of activity is similar to that of quinidine. It has been previously demonstrated that imipramine inhibits the aggregate time-dependent outward K+ current (IK). IK is composed of at least two components: a slowly activating La(3+)-resistant delayed rectifying current (IK,s) and a r...

Recent neutron scattering measurements reveal spin and charge ordering in the half-doped nickelate, La3/2Sr1/2NiO4. Many of the features of the magnetic excitations have been explained in terms of the spin waves of diagonal stripes with a magnetic coupling structure which is fourfold symmetric. However, an optical mode dispersing away from the , point was not captured by this theory. We show he...

O. Delaire,1 A. F. May,2 M. A. McGuire,3 W. D. Porter,3 M. S. Lucas,1 M. B. Stone,1 D. L. Abernathy,1 V. A. Ravi,4,5 S. A. Firdosy,4 and G. J. Snyder2 1Neutron Scattering Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA 2California Institute of Technology, Pasadena, California 91125, USA 3Materials Science and Technology Division, Oak Ridge National Laboratory, O...

In this work, pure Sr2CeO4 and Sr2CeO4: x=0.01, 0.1, 0.2, 0.5, 1.0mol% Dy3+, 0.5mol% La3+ phosphors were synthesized by solid state reaction method. X-ray diffraction (XRD) patterns confirmed that the samples exhibited an orthorhombic crystal structure. Room temperature photoluminescence (PL) analysis indicated that the excitation peak at around 260 nm, and all the samples showed intense blue e...