BACKGROUND Lysosomal acid lipase (LAL) controls development and homeostasis of myeloid lineage cells. Loss of the lysosomal acid lipase (LAL) function leads to expansion of myeloid-derived suppressive cells (MDSCs) that cause myeloproliferative neoplasm. METHODOLOGY/PRINCIPAL FINDINGS Affymetrix GeneChip microarray analysis identified detailed intrinsic defects in Ly6G(+) myeloid lineage cell...

Duck eggs were pickled in alkali for 20 days to prepare Pidan. The extent of the degradation of compositional amino acids, the formation of lysinoalanine (LAL) in Pidan, and the relationship between the formation of LAL and the racemization values of D-serine and D-aspartic acid in Pidan albumen during the pickling period were investigated. Results showed that the remaining percentages of Cys, ...

Horseshoe crabs (Limulus polyphemus) are bled by biomedical companies for the extraction of Limulus Amoebocyte Lysate (LAL), a clotting agent used in the detection of endotoxins. In 1998, the Atlantic States Marine Fisheries Conunission mandated tliat all biomedical companies collecting horseshoe crabs for the production of LAL study tl1e horseshoe crab mortality rates resulting from the compan...

The Relationship between Emotional Intelligence and Literacy Achievement of Secondary Students by David P. Jones MA, Marygrove College, 2004 BS, The College of New Jersey, 1992 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Education Walden University June 2013 Abstract Proficiency in language arts and communication skills is essential t...

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in the cell. The downstream metabolites of these compounds serve as hormonal ligands for nuclear receptors and transcription factors. Genetic ablation of the lal gene in the mouse caused malformation of macrophages and inflammation-triggered multiple pathogenic phenotypes in ...

anguage assessment literacy (LAL), mainly defined as knowledge and skills of language assessment, in the last two decades, has started to receive the attention it deserves. As one of the significant findings, based on a plethora of research, many second language (L2) teachers have been indicated to be professionally incompetent in terms of LAL. To investigate the status of LAL among Ira...