Antifungal prophylaxis for patients at high risk for aspergillosis is appealing due to the high morbidity and mortality of aspergillosis despite antifungal therapy (1–3). While voriconazole is a logical option, reports of breakthrough mucormycosis are a cause for concern (5). To identify alternative prophylactic strategies, we utilized our novel, inhalational model of pulmonary Aspergillus fumi...

We have studied the immunological relatedness of LamB proteins from a wide range of enterobacterial species, using antibodies directed against denatured Escherichia coli K12 and Klebsiella pneumoniae LamB proteins (LamBE.c. and LamBK.p., respectively), and anti-peptide antibodies directed against 10 distinct loops of LamB from E. coli K12 predicted to protrude either side of the outer membrane....

Neonatal lamb mortality is a major factor affecting profitability in the sheep industry, and lamb thermogenesis is a key element in neonatal lamb survival. Increased lamb vigor has been reported when ewes were supplemented during late gestation with algae-derived docosahexaenoic acid (DHA); however, the effects of DHA on lamb thermogenesis and immunocompetence have not been investigated. Eighty...

in this study, in addition to estimating meat demand, live animal supply and marketing services supply for beef and lamb, economic behavior of marketing margin with respect to determinants of meat demand, live animal supply and marketing services supply have been evaluated for years 1998-2004. results indicate that, as examples, beef and lamb marketing margin elasticity with respect to feed pri...

OBJECTIVE The objective of this study was to evaluate the effects of ageing time of lamb loins prior to freezing on technological characteristics and oxidation stability of coarse ground lamb loin sausage using in a model system. METHODS Lamb loins (M. longissimus lumborum, n = 25) were aged at -1.5°C for 0, 1, 2, 3, and 8 wk and then frozen for the remaining days (a total of 30 wk). The aged...

Production data from 681 yearling ewes were evaluated for the effect of ewe breed and management system on fertility, prolificacy, lamb birth weight, lamb survival, lamb weaning weight, ewe fleece weight, and total lamb weight weaned per ewe exposed. Two hundred seven straightbred Targhee (T) and 474 1/4 Finn-1/4 Dorset-1/2 Targhee (FDT) crossbred ewes managed in a range or farm flock system we...

BACKGROUND India is home to 60% of the total global visceral leishmaniasis (VL) population. Use of long-term oral (e.g. miltefosine) and parenteral drugs, considered the mainstay for treatment of VL, is now faced with increased resistance, decreased efficacy, low compliance and safety issues. The authors evaluated the efficacy and safety of an alternate treatment option, i.e. single infusion of...

BACKGROUND In a major clinical trial, caspofungin was as efficacious as liposomal amphotericin B (LAmB) for empirical therapy in febrile neutropenia. The current study sought to evaluate the economic impact of caspofungin as compared with LAmB for febrile neutropenia in Australia. METHODS A decision analytic model was developed to capture the downstream consequences of the empirical antifunga...

Data from the Montana State University Targhee flock were used to estimate genetic and environmental relationships between lamb BW and adult ewe BW, condition score, and prolificacy. The flock was managed under commercial western range conditions typical of the area. Data included records from 12,154 lambs born to 2,930 dams and 200 rams between 1960 and 2005. Lamb traits included BW at birth a...

Overexpression of OmpC protein from an inducible plasmid vector reduced the amount of the precursor form of LamB protein in LamB signal sequence mutants. The stability of the precursor form of LamB protein was not affected, indicating that the effect of OmpC overexpression was on the synthesis of the precursor rather than on degradation. These results indicate that a functional signal sequence ...