Three-dimensional simulations of the single-phase laminar flow and forced convective heat transfer of water in microchannels with small rectangular sections having specific hydraulic diameters and distinct geometric configurations were investigated numerically. The numerical results indicated that the laminar heat transfer was to be dependent upon the aspect ratio and the ratio of the hydraulic...

BACKGROUND Steady laminar flow is atheroprotective, in part because of its antiinflammatory effects on vascular endothelial cells (ECs). We studied the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) in ECs in response to laminar flow and the associated antiinflammatory effect. METHODS AND RESULTS Using flow channel with cultured ECs, we found that laminar flow acti...

This study was designed to elucidate the mechanism underlying the inhibition of endothelial cell growth by laminar shear stress. Tumor suppressor gene p53 was increased in bovine aortic endothelial cells subjected to 24 h of laminar shear stress at 3 dynes (1 dyne = 10 microN)/cm(2) or higher, but not at 1.5 dynes/cm(2). One of the mechanisms of the shear-induced increase in p53 is its stabiliz...

Endocrinopathic laminitis (EL) is a vascular condition of the equine hoof resulting in severe lameness with both welfare and economic implications. EL occurs in association with equine metabolic syndrome and equine Cushing's disease. Vascular dysfunction, most commonly due to endothelial dysfunction, is associated with cardiovascular risk in people with metabolic syndrome and Cushing's syndrome...

We investigated the presence and localization of glycosaminoglycans in basal laminar deposit and drusen in age-related maculopathy. Conventional histological staining techniques and monoclonal antibodies specific for several glycosaminoglycans were used on paraffin-embedded human maculae. Furthermore, macular homogenates were analyzed with two-dimensional electrophoresis. Quantitative analysis ...

A new modeling strategy is developed to introduce tabulated chemistry methods in LES of turbulent premixed combustion. The objective is to recover the correct laminar flame propagation speed of the filtered flame front when subgrid scale turbulence vanishes. The filtered flame structure is mapped by 1-D filtered laminar premixed flames. Closure of the filtered progress variable and the energy b...

5 Simple example problems 20 5.1 Cantilever beam . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 5.2 Frequency calculation of a beam loaded by compressive forces . . 27 5.3 Frequency calculation of a rotating disk on a slender shaft . . . . 29 5.4 Thermal calculation of a furnace . . . . . . . . . . . . . . . . . . 35 5.5 Seepage under a dam . . . . . . . . . . . . . . . . . . . . . . ...

We define a laminar branched surface to be a branched surface satisfying the following conditions: (1) Its horizontal boundary is incompressible; (2) there is no monogon; (3) there is no Reeb component; (4) there is no sink disk (after eliminating trivial bubbles in the branched surface). The first three conditions are standard in the theory of branched surfaces, and a sink disk is a disk branc...