Guanosine triphosphate binding proteincoupled receptors (GPCRs) represent one of the largest and most important classes of pharmaceutical drug targets. Approximately 48% of all GPCRs couple through adenylate cyclase making the need for a robust cAMP detection method critical. We have developed a secondgeneration LANCE® time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay d...

Lance nematodes (Hoplolaimus spp.) feed on the roots of a wide range of plants, some of which are agronomic crops. Morphometric values of amphimictic lance nematode species overlap considerably, and useful morphological characters for their discrimination require high magnification and significant diagnostic time. Given their morphological similarity, these Hoplolaimus species provide an intere...

Genetic and environmental factors that affect the formation of glutenin macropolymer (GMP) particles were investigated by growing Lance 5C 10, Lance 2C12, Warigal 5C10 and Warigal 2C12 lines under widely differing temperature regimes in greenhouse conditions. The GMP characteristics and mixing properties of flour extracted from mature wheat kernels were systematically studied. The amount of GMP...

The concept of admissibility with respect to clustering algorithms was introduced by Fisher and Van Ness (1971). They defined types of admissibility of an algorithm and indicated the relationships between these admissibilities and popular clustering algorithms. In recent years, admissibility with respect to space distortion (See, Lance and Williams, 1967) has been proposed by Chen and Van Ness ...

A bedside technique for evaluating the behavioural response of healthy neonates to pain was assessed. Thirty six term infants (median gestational age 40 weeks; median postnatal age 4 days) and 31 preterm infants (median gestational age 34 weeks; median postnatal age 4 days) were assessed at the cotside for their response to heel preparation and heel lance for routine blood sampling. The facial ...

Perampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that has been licensed and marketed as antiepileptic drug (AED) indicated for patients with partial-onset and primary generalized tonic-clonic seizures. A positive effect was reported in some patients with epileptic myoclonic jerks in idiopathic genera...

Bothrops asper is the most dangerous poisonous snake in Southern Mexico and Central America. Its venom is known to produce myonecrosis. The myotoxins present in the venom penetrate muscle cells altering ionic transport through the sarcoplasmic reticulum membrane causing an increase in the flow of calcium into the sarcoplasm resulting in a calcium overload. This calcium overload leads to phospho...

für Naturforschung in cooperation with the Max Planck Society for the Advancement of Science under a Creative Commons Attribution 4.0 International License. Dieses Werk wurde im Jahr 2013 vom Verlag Zeitschrift für Naturforschung in Zusammenarbeit mit der Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. digitalisiert und unter folgender Lizenz veröffentlicht: Creative Commons Namen...