In the present study, the in vogue ethnoveterinary practices in the Mansehra District of Pakistan were documented. Results revealed that 35 plant species representing 25 families were used in the area to treat the ailing animals. Most frequently used plants were from the families Apiaceae, Brassicaceae, Compositae, Pinaceae, Poaceae and Verbenaceae families. Other commonly used ingredients of e...

A novel group of nitrogen-fixing plant-associated Burkholderia species has emerged in the last few years. The purpose of this investigation was to determine if these species possess an N-acylhomoserine lactone (AHL) quorum-sensing (QS) cell-cell signalling system, and whether it is important for nitrogen fixation and other phenotypic features in Burkholderia kururiensis. It was determined that ...

Experiments examining the social dynamics of bacterial quorum sensing (QS) have focused on mutants which do not respond to signals and the role of QSregulated exoproducts as public goods. The potential for QS signal molecules to themselves be social public goods has received much less attention. Here, we analyze how signal-deficient (lasI) mutants of the opportunistic pathogen Pseudomonas aerug...

Development of β-lactam resistance, production of alginate and modulation of virulence factor expression that alters host immune responses are the hallmarks of chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. In this study, we propose that a co-regulatory network exists between these mechanisms. We compared the promoter activities of ampR, algT/U, lasR, lasI, rhlR, rhlI and...

In the opportunistic human pathogen Pseudomonas aeruginosa, quorum sensing (QS) is crucial for virulence. The RsaL protein directly represses the transcription of lasI, the synthase gene of the main QS signal molecule. On the basis of sequence homology, RsaL cannot be predicted to belong to any class of characterized DNA-binding proteins. In this study, an in silico model of the RsaL structure ...

Posttranscriptional control is known to contribute to the regulation of secondary metabolism and virulence determinants in certain gram-negative bacteria. Here we report the isolation of a Pseudomonas aeruginosa gene which encodes a global translational regulatory protein, RsmA (regulator of secondary metabolites). Overexpression of rsmA resulted in a substantial reduction in the levels of extr...

Background Anemia is a condition characterised by low haemoglobin concentration, which common in elderly populations. In India, anemia widely researched childhood development and women of reproductive age, although studies older populations are lacking. The Longitudinal Ageing Study India - Diagnosis Dementia (LASI-DAD) dataset an ideal cohort to better understand the potential impact anaemia c...