In addition to productive lytic infections, herpesviruses such as human cytomegalovirus (HCMV) establish a reservoir of latently infected cells that permit lifelong colonization of the host. When latency is established, the viral immediate-early (IE) genes that initiate the lytic replication cycle are not expressed. HCMV IE gene expression at the start of a lytic infection is facilitated by the...

Herpes simplex virus type 1 establishes latent infections in sensory neurons. During latency only one locus, the latency-associated transcript (LAT), is abundantly transcribed. Several lines of evidence suggest that this locus is required for the efficient reactivation from latency in experimental models. However, it is not yet clear whether this is a direct effect on the reactivation process p...

Latent TB infection (LTBI) screening and treatment in HIV-positive individuals in the UK is advocated by the British HIV Association (BHIVA) and National Institute for Health and Care Excellence (NICE), although each recommends differing strategies. We undertook an evaluation of UK practice, relating the responses to the local HIV/TB disease burden. 162 of 188 (86%) UK geographical areas respon...

Long-term ovine fibroblast cultures contain replicative-competent lentiviruses in a latent form. This in vitro phenomenon, never described previously for lentiviruses, was clearly demonstrated by activating the expression of latent viruses with various inducing cell treatments, some of which were efficient in inducing endogenous retroviruses or latent herpesviruses. Activated lentiviruses were ...

Infection with "pathogenic" microorganisms but without clinically apparent disease has been variously defined as latent, subclinical, dormant , occult, and inapparent. These terms are employed with varying meanings by clinicians, veterinarians, phytopathologists, and other biologists. For the sake of greater consistency, however, three general categories of infections without apparent disease h...

A possible etiologic relationship between maternal asymptomatic genital HVH infection and pre-term labor was discussed on the base of the results of the investigation performed in this study. Latent HVH infection was diagnosed by the test of microneutralization. Asymptomatic HVH vaginal and cervical shedding was investigated by indirect immunofluorescence and cytologically. The incidence of lat...