the present research was done to examine the efficacy of psychosocial skills training on psychological and job stress management of bus drivers. accessible sampling method was utilized and the sample consisted of 157 bus drivers in the city of tehran. the research method is quasi- experimental with pretest-posttest. job stress inventory and stress response inventory were administered before and...

We investigated whether restraint stress interferes with lead-induced suppressed fertility in rats. Male Wister rats (weighing 200 ± 10 g in the beginning of the experiment) were subjected to either restraint stress (5 hours/day) or exposed to lead (0.15%) or both for 60 days. To assess the fertility, control and experimental males were cohabited with sexually mature normal females. No signific...

Lead is harmful for human health and animals. Proanthocyanidins (PCs), a natural antioxidant, possess a broad spectrum of pharmacological and medicinal properties. However, its protective effects against lead-induced liver damage have not been clarified. This study was aimed to evaluate the protective effect of PCs on the hepatotoxicity of male Kunming mice induced by chronic lead exposure. A t...

This study examined whether lead-induced alterations in selected parameters that are indicative of oxidative stress accompany the toxic effects of lead in red blood cells (RBCs) in vivo. It also explored the possibility that treatment with N-acetylcysteine (NAC) or succimer (meso-2,3-dimercaptosuccinic acid) was capable of reversing parameters indicative of lead-induced oxidative stress. Fisher...

Evidence implicating oxidative stress in toxicity during lead intoxication in vivo has opened new avenues for investigation of the mechanisms of lead-induced immunosuppression. The current study explores the possibility that lead-induced oxidative stress contributes to the immunosuppression observed during lead poisoning. Fisher 344 rats were exposed to 2,000 ppm lead acetate in their drinking ...

The objective of the present study was to evaluate the protective efficacy of gossypin coadministration during lead-ethanol co-exposure. In one of our earlier study we reported the protective efficacy of gossypin against lead induced oxidative stress and it was of interest to observe the efficacy in the situation of combined lead-ethanol exposure. Animals were exposed to lead as lead nitrate (2...

Oxidative stress is proposed as a molecular mechanism in lead toxicity, which suggests that antioxidants might play a role in the treatment of lead poisoning. The present study was designed to investigate whether taurine has a beneficial effect both on Chinese hamster ovary (CHO) cells and on Fisher 344 (F344) rats following lead exposure. Therefore, oxidative stress parameters (glutathione, ma...