BACKGROUND Pulmonary arterial hypertension (PAH) is known to trigger right ventricular (RV) remodeling that might compromise left ventricular (LV) filling due to inter-ventricular interdependence. In this study, we aimed to examine standard echocardiographic measurements of LV diastolic function in PAH patients. METHODS In this retrospective study, we identified clinical as well as complete e...

Background Abundant, abnormal myocardial trabeculae define left ventricular noncompaction (LVNC) but measurement is difficult and at least 5 techniques are described. We hypothesized that part of the reason for difficulties was that LV trabeculae were fractal in nature and beyond the simple geometry of 1 or 2 dimensional (2D) measurement. We designed and validated a new, rapid, clinically appli...

Introduction Persistent left superior vena cava (PLSVC) is a congenital developmental abnormality of the sinus venosus with an incidence of 0.47% in patients undergoing cardiac implantable electronic devices. The 2 variants include a double superior vena cava (right and left SVC, with or without an innominate vein connecting the two) or a single left-sided SVC (without a right SVC), which may o...

We investigated whether plasma brain and atrial natriuretic peptide (BNP and ANP, respectively) levels could reflect left ventricular (LV) geometry and function in patients with mild to moderate essential hypertension. A positive correlation was found between LV mass index (LVMI) and plasma ANP levels in 84 untreated, hypertensive patients, but not between LVMI and plasma BNP levels. As compare...

Pathological cardiac hypertrophy was produced by partial abdominal aortic constriction (PAAC) for 4 wk, while physiological cardiac hypertrophy was produced by chronic swimming training (CST) for 8 wk in rats. Pentoxifylline (30 mg/kg, 300 mg/kg i.p., day-1) treatment was started three days before PAAC and CST and it was continued for 4 wk in PAAC and 8 wk in CST experimental model. The left ve...

To investigate whether circulating blood volume contributes to left ventricular (LV) geometry, 60 outpatients with untreated, mild to moderate essential hypertension and 45 normotensives were studied. Based on echocardiographic LV mass index and relative wall thickness, four patterns of LV geometry, i.e., normal left ventricle, concentric remodeling, eccentric hypertrophy and concentric hypertr...

introduction: although left ventricular(lv) function parameters measured by gated myocardial perfusion spect (gspect) have been validated, experimental data have revealed that the calculated the lv function parameters using gspect are affected by patient populations as well as particular acquisition and processing conditions. we tried to determine the normal values of gspect in an iranian popul...

BACKGROUND Data regarding the familial aggregation of left ventricular (LV) geometry and its relations to parental heart failure (HF) are limited. METHODS AND RESULTS We evaluated concordance of LV geometry within 1093 nuclear families in 5758 participants of the original (parents) (n=2351) and offspring (n=3407) cohorts of the Framingham Heart Study undergoing routine echocardiography in mid...

Death and morbidity in pulmonary arterial hypertension (PAH) are often due to right ventricular (RV) failure and associated left ventricular (LV) dysfunction. We investigated regional myocardial remodeling and function as the basis for adverse ventricular-ventricular interactions in experimental chronic RV pressure overload. Two distinct animal models were studied: A rabbit model of increased R...