Psychodopygus wellcomei (Diptera: Psychodidae), vector of Leishmania braziliensis braziliensis - causative agent of cutaneous leishmaniasis in Brazil, cannot be distinguished from sympatric P. complexus either by morphometrics or isoenzyme profiles. We report here the use of cuticular hydrocarbon analysis in the successful separation of individual female P. wellcomei and P. complexus. This tech...

BACKGROUND American Tegumentary Leishmaniasis (ATL) caused by Leishmania braziliensis is endemic in Corte de Pedra, Northeast Brazil. Most L. braziliensis infections manifest as localized cutaneous leishmaniasis (CL). Disseminated manifestations include mucosal leishmaniasis (ML), present at a low constant level for several decades, and newly emerging disseminated leishmaniasis (DL). Surprising...

Both Leishmania major and L. braziliensis induce cutaneous leishmaniasis in BALB/c mice. Whereas BALB/c mice die of infection with L. major, they cure an infection with L. braziliensis. We report here that after curing an infection with L. braziliensis, BALB/c mice are resistant to challenge with L. major. When challenged with L. major, L. braziliensis pre-treated BALB/c mice mounted a delayed-...

introduction: the topical and intradermal photodynamic therapy (pdt) effect of methylene blue (mb) using light-emitting diode (led) as light source (mb/led-pdt) in the treatment of lesions of american cutaneous leishmaniasis (acl) caused by leishmania braziliensis in hamsters were investigated. methods: hamsters were infected in the footpad with 4×107 promastigotes of l. braziliensis and divide...

BACKGROUND Leishmania transmission occurs in the presence of insect saliva. Immunity to Phlebotomus papatasi or Lutzomyia longipalpis saliva or salivary components confers protection against an infection by Leishmania in the presence of the homologous saliva. However, immunization with Lutzomyia intermedia saliva did not protect mice against Leishmania braziliensis plus Lu. intermedia saliva. I...

Inositol phosphorylceramide (IPC), the major sphingolipid in the genus Leishmania but not found in mammals, is considered a potentially useful target for chemotherapy against leishmaniasis. Leishmania (Viannia) braziliensis is endemic in Latin America and causes American tegumentary leishmaniasis. We demonstrated that IPCs are localized internally in parasites, using a specific monoclonal antib...

Citation: Nunes S, Silva IB, Ampuero MR, Noronha ALLd, Souza LCLd, Correia TC, Khouri R, Boaventura VS, Barral A, Ramos PIP, Brodskyn C, Oliveira PRS and Tavares NM (2018) Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused by Leishmania braziliensis. Front. Immunol. 9:640. doi: 10.3389/fimm...

Triatoma melanocephala is a rare species of Hemiptera that belongs to the Brasiliensis subcomplex. This subcomplex is composed of cryptic species, and the basic number of chromosomes for triatomines of this subcomplex is 2n = 22; however, T. melanocephala showed a karyotype of 2n = 24 (20A + X(1)X(2)X(3)Y). Thus, this study allowed us to describe the karyotype of the species and, more specifica...

We have reported the predominance of Lutzo­ myia whitmani in the peridomicile in our field project area of Tres Braços, Bahia3 where 99% of phlebotomines captured were of this species. This is the suspected vector of Leishmania viannia braziliensis (Lvb) and to date three wild caught flies have been found to harbour this parasite of over 18,000 dissected2. We wish to record here the presence of...