LEOPARD syndrome (LS) is a rare hereditary disorder in Asian countries. This syndrome consists of multiple systemic abnormalities. In particular, characteristic cardiovascular effects in LS may include variable clinical manifestations from benign to life-threatening courses. The cardiac effects of this syndrome consist of left ventricular hypertrophy (LVH), pulmonary stenosis (PS), coronary art...

Noonan syndrome (NS) is one of the most common syndromes transmitted by a mendelian mode. In recent years, germline mutations that affect components of the RAS-MAPK (mitogen-activated protein kinase) pathway were shown to be involved in the pathogenesis of NS and four rare syndromes with clinical features overlapping with NS: Leopard syndrome, cardio-facio-cutaneous syndrome, Costello syndrome ...

Leopard, a well-known zebrafish mutant that has a spotted skin pattern instead of stripes, is a model for the study of pigment patterning. To understand the mechanisms underlying stripe formation, as well as the spot variation observed in leopard, we sought to identify the gene responsible for this phenotype. Using positional cloning, we identified the leopard gene as an orthologue of the mamma...

We conducted surveys above 3000 m elevation in eight protected areas of Uttarakhand and Himachal Pradesh. These surveys provide new information on snow leopard in Uttarakhand on the basis of indirect evidence such as pugmark and scat. Snow leopard evidence (n = 13) were found between 3190 and 4115 m elevation. On an average, scats (n = 09) of snow leopard were found for every 56 km walked and p...

No Luck? renal adenocarcinomas were detected at autopsy of 1216 northern leopard frogs (Rana pipiens) collected in Minnesota during the spring and autumn of 1978 and the spring of 1979, seasons in which the tumor was formerly obtained with a high frequency. The prevalence of renal tumors has been declining in Minnesota since at least 1966, and R. pipiens has become progressively scarce in Minne...

Neurointensivist, Neuro/Cardio ICU, Hospital Espanhol, Salvador BA, Brazil; Chief, Neurology Department, Hospital São Rafael, Salvador BA, Brazil; Coordinator, Adult ICU, Hospital Santo Amaro, José Oliveira Foundation, Salvador BA, Brazil; Chief, Neurology Department and Neuro/cardio ICU, Hospital Espanhol, Salvador BA, Brazil; Coordinator, Adult ICU, Hospital da Cidade, Salvador BA, Brazil; Su...

Spot pattern of Leopard Danio is caused by the mutation in zebrafish connexin41.8 gene