OBJECTIVE The aim of this investigation was to compare the pharmacokinetics of lidocaine and prilocaine in two groups of 10 patients undergoing intravenous regional anaesthesia. METHOD The study had a randomized design. The patients were allocated to one of the two groups of 10. Each group received either lidocaine (200 mg = 0.855 mM) or prilocaine (Citanest, 200 mg = 0.909 mM), injected intr...

PURPOSE It has been reported that the addition of epinephrine and/or bicarbonate to local anesthetic enhances the depth of epidural blockade and that initial partial bolus injection results in greater caudal spread. We evaluated the anesthetic effects of lidocaine with epinephrine and/or bicarbonate injected into the epidural space by bolus or catheter injection. METHODS Forty-four patients u...

Lidocaine is a frequently administered anti-arrhythmic drug, particularly useful in emergency situations because of its rapid onset of action (1). Therapeutic drug monitoring of lidocaine is recommended because of its potent central nervous system toxicity. Moreover, lidocaine has been implicated in numerous accidental and homicidal deaths (2). Thus its chemical stability in patients’ specimens...

Pharmacokinetics and Metabolism: Lidocaine may be absorbed following topical administration to mucous membranes, its rate and extent of absorption depending upon concentration and total dose administered, the specific site of application, and duration of exposure. In general, the rate of absorption of local anesthetic agents following topical application occurs most rapidly after intratracheal ...

Topical anesthetics play an important role in the practice of ophthalmology, both for procedures in the office and in the operating room. The need for safe, long-acting topical ocular anesthetic agents is ongoing, and has been highlighted by the increase of intravitreal administration of pharmacologic agents. Current practices for ocular anesthesia include subconjunctival injection of 2% aqueou...

Higher incidence and worse outcomes of laryngospasm during general anesthesia in children than adults have been reported for many years, but few prevention measures are put forward. Efficacy of lidocaine in laryngospasm prevention has been argued for many years and we decided to design this network meta-analysis to assess the efficacy of lidocaine. We conducted an electronic search of six sourc...

BACKGROUND The authors studied the hemodynamic effect influent by using the novel high concentration of lidocaine HCl for surgical removal impacted lower third molar. The objective of this study was to evaluate the hemodynamic change when using different concentrations of lidocaine in impacted lower third molar surgery. METHODS Split mouth single blind study comprising 31 healthy patients wit...

Both I and 2% lidocaine solutions were clinically evaluated for effectiveness in the induction of profound local anesthesia in adolescents. This effectiveness was measured by the ability to extract healthy premolars without discomfort. In a cross-arch design using paired premolars the double-blind administration of 1% lidocaine was found to be as effective as 2% lidocaine in induction of local ...

background: interaction between local anesthetic solution, lidocaine hydrochloride (with and without adrenaline), and root canal irrigants such as sodium hypochlorite (naocl), ethylene diamine tetra-acetic acid (edta), and chlorhexidine (chx) has not been studied earlier. hence, the purpose of this in vitro study was to evaluate the chemical interaction between 2% lidocaine hydrochloride (with ...

Tonsils are located in the upper airway.serious complications may threaen the patients during and following surgical operations in this area.this study was done to assess the effectiveness of local lidocaine infiltration for redusing complications of tonsillectomy.in this study,74 patients were randomly selected.37 patients received local lidocaine infiltration(2ml of 2% lidocaine)in the tonsil...