نتایج جستجو برای: ligb
تعداد نتایج: 76 فیلتر نتایج به سال:
Subunit vaccines are a potential intervention strategy against leptospirosis, which is a major public health problem in developing countries and a veterinary disease in livestock and companion animals worldwide. Leptospiral immunoglobulin-like (Lig) proteins are a family of surface-exposed determinants that have Ig-like repeat domains found in virulence factors such as intimin and invasin. We e...
BACKGROUND Leptospirosis has been implicated as a severe and fatal form of disease in Mayotte, a French-administrated territory located in the Comoros archipelago (southwestern Indian Ocean). To date, Leptospira isolates have never been isolated in this endemic region. METHODS AND FINDINGS Leptospires were isolated from blood samples from 22 patients with febrile illness during a 17-month per...
Betalains are pigments that replace anthocyanins in the majority of families of the plant order Caryophyllales. Betalamic acid is the common chromophore of betalains. The key enzyme of the betalain biosynthetic pathway is an extradiol dioxygenase that opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymati...
Limited research has been conducted on the role of transcriptional regulators in relation to virulence in Leptospira interrogans, the etiological agent of leptospirosis. Here, we identify an L. interrogans locus that encodes a sensor protein, an anti-sigma factor antagonist, and two genes encoding proteins of unknown function. Transposon insertion into the gene encoding the sensor protein led t...
زمینه: لپتوسپیروز بیماری عفونی میباشد که بهعنوان مهمترین بیماری زئونوز شایع در جهان مطرح شده است. LigBیکی از مهمترین پروتئینهای غشاء خارجی لپتوسپیرا میباشد، ایمونوژن میباشد و تنها در لپتوسپیراهای بیماریزا وجود دارد. هدف این پژوهش تشخیص مولکولی لپتوسپیراهای بیماریزا بهروش PCR بر مبنای ژن ligB میباشد. مواد و روشها: در این بررسی از پنج سرووار بیماریزای لپتوسپیرا و یک سرووار غیر بیماری...
Reverse vaccinology (RV) has been widely used for screening of surface-exposed proteins (PSEs) of important pathogens, including outer membrane proteins (OMPs), and extracellular proteins (ECPs) as potential vaccine candidates. In this study, we applied a novel RV negative strategy and a pan-genome analysis for screening of PSEs from 17 L. interrogans strains covering 11 predominately epidemic ...
In this work we have characterized the galA gene product from Pseudomonas putida KT2440, a ring-cleavage dioxygenase that acts specifically on gallate to produce 4-oxalomesaconate. The protein is a trimer composed by three identical subunits of 47.6 kDa (419 amino acids) that uses Fe2+ as the main cofactor. The gallate dioxygenase showed maximum activity at pH 7.0, and the Km and Vmax values fo...
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