In this paper, we study the detection boundary for minimax hypothesis testing in the context of high-dimensional, sparse binary regression models. Motivated by genetic sequencing association studies for rare variant effects, we investigate the complexity of the hypothesis testing problem when the design matrix is sparse. We observe a new phenomenon in the behavior of detection boundary which do...

The existence of multiple likelihood maxima necessitates algorithms that explore a large part of the tree space. However, because of computational constraints, stepwise addition-based tree-searching methods do not allow for this exploration in reasonable time. Here, I present an algorithm that increases the speed at which the likelihood landscape can be explored. The iterative algorithm combine...

This approach has several advantages: (1) there is no need to estimate the variance/covariance at all, which may become prohibitively complicated for other procedures that requires the estimation of such. (2) When inverting the tests to obtain confidence regions/intervals, this procedure inherits all the good properties of a likelihood ratio test. (3) Free software implementation of the test is...

A new approach of parameterization is proposed to construct a general goodnessof-fit test. It can not only generate traditional tests (including the Kolmogorov–Smirnov, Cramér– von Mises and Anderson–Darling tests) but also produce new types of omnibus tests, which are generally much more powerful than the old ones.

The method of maximum likelihood (ML), introduced by Fisher (1921), is widely used in human and quantitative genetics and we draw upon this approach throughout the book, especially in Chapters 13–16 (mixture distributions) and 26–27 (variance component estimation). Weir (1996) gives a useful introduction with genetic applications, while Kendall and Stuart (1979) and Edwards (1992) provide more ...

Estimator variables are factors that can affect the accuracy of eyewitness identifications but that are outside of the control of the criminal justice system. Examples include (1) the duration of exposure to the perpetrator, (2) the passage of time between the crime and the identification (retention interval), (3) the distance between the witness and the perpetrator at the time of the crime. Su...

In this paper we compare the properties of four different general approaches for testing the ratio of two Poisson rates. Asymptotically normal tests, tests based on approximate p -values, exact conditional tests, and a likelihood ratio test are considered. The properties and power performance of these tests are studied by a Monte Carlo simulation experiment. Sample size calculation formulae are...