To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing techn...

Nuclear migration and anchorage within developing and adult tissues relies heavily upon large macromolecular protein assemblies called LInkers of the Nucleoskeleton and Cytoskeleton (LINC complexes). These protein scaffolds span the nuclear envelope and connect the interior of the nucleus to components of the surrounding cytoplasmic cytoskeleton. LINC complexes consist of two evolutionary-conse...

Long intergenic non-coding RNAs (lincRNA) are members of a class of non-protein-coding RNA transcript that has recently been shown to contribute to gene regulatory processes and disease etiology. It has been hypothesized that lincRNAs influence disease risk through the regulation of mRNA transcription [88], possibly by interacting with regulatory proteins such as chromatin-modifying complexes [...

Power amplifiers (PAs) are inherently nonlinear devices and they are present in all transmitters of a communication equipment. As a result of transmitter nonlinearities, the transmitted signal spectrum expands into adjacent channels. Several linearizing techniques for power amplifiers have been proposed, but the most existing architectures assume that the PA has a memoryless nonlinearity. For w...

While the mechanisms by which chemical signals control cell fate have been well studied, impact of mechanical inputs on decisions is not understood. Here, using well-defined system keratinocyte differentiation in skin, we examine whether and how direct force transmission to nucleus regulates epidermal fate. Using a molecular biosensor, find that tension through linker nucleoskeleton cytoskeleto...

A high-stakes Portfolio-Based Language Assessment (PBLA) protocol that was fully implemented in all Instruction for Newcomers to Canada (LINC) programs 2019 requires instructors and students set language-learning goals complete, compile, reflect on numerous authentic language tasks. Due the barriers incurred when communicating with beginner English-as-a-second-language literacy learners (BELLs)...

A cell's ability to recognize and adapt to the physical environment is central to its survival and function, but how mechanical cues are perceived and transduced into intracellular signals remains unclear. In mesenchymal stem cells (MSCs), high-magnitude substrate strain (HMS, ≥2%) effectively suppresses adipogenesis via induction of focal adhesion (FA) kinase (FAK)/mTORC2/Akt signaling generat...