Generalized morphea is a subtype of localized scleroderma, which lacks systemic manifestations and displays widespread, multiple, well-circumscribed, indurated plaques. We represent a 46-year-old woman with generalized morphea. More than 3 years ago she developed multiple, nonpruritic plaques symmetrically on the trunk and extremities. The patient’s clinical history, laboratory analysis and his...

We present a case of a 69-year-old woman who received external beam radiation for the treatment of breast cancer. Seven months later, she developed generalized morphea involving the area of irradiated skin of the breast as well as distant sites of the groin and distal lower extremity. Postirradiation morphea is an uncommon yet well-documented phenomenon, usually confined to the radiated site an...

Granuloma annulare(GA) is an inflammatory benign cutaneous disease of unknown etiology that may manifest different clinical features. The most common presentation or classic form of the disease is manifested as flesh colored, annular grouped papules, commonly involving the hands and feet. Various skin injuries and infections have been reported to trigger GA, including insect bites, warts,...

INTRODUCTION Morphea is an inflammatory skin disorder characterized by excessive collagen deposition. Although treatment algorithms for morphea subtypes have been suggested, no consistent recommendations are available. This study attempts to evaluate the clinical efficacy of methotrexate (MTX) as monotherapy in refractory generalized morphea. METHODS It is a retrospective study, including 20 ...

Bullous morphea is a rare form of morphea characterized with bullae on or around atrophic morphea plaques. Whereas lichen sclerosus et atrophicus (LSA) is a disease the etiology of which is not fully known, and which is characterized with sclerosis. Coexistence of morphea and LSA has been identified in some cases. Some authors believe that these two diseases are different manifestations which a...

INTRODUCTION Morphea is a disease included in the group of scleroderma type autoimmune diseases. Interleukin (IL)-17A may play a role at every stage of its pathogenesis. The study aimed at evaluation of IL-17A and IL-23 (as the main cytokine which is supposed to stimulate and maintain synthesis of IL-17) in pathogenesis of morphea. MATERIAL AND METHODS The studies were performed on 41 blood s...

BACKGROUND Interstitial mycosis fungoides (IMF) is a rare variant of mycosis fungoides that resembles the interstitial form of granuloma annulare and inflammatory morphea. IMF has received little attention in the literature. METHODS Clinical, histological, immunophenotypical, and genotypical findings of five cases of IMF were reviewed. The histological and immunophenotypical findings were com...

Morphea is an inflammatory skin disease resulting in sclerosis of underlying tissues which causes functional limitations and cosmetic sequalae that negatively impact quality life. Previous health-related life (HRQoL) patient reported outcome (PRO) studies have focused on children a validated measure, the Localized Scleroderma Quality Life Instrument (LoSQI), has been developed. No PRO measure e...

A 67-year-old woman was evaluated for a worsening asymptomatic rash located on her torso, back, and legs. She denied any chills or fevers, reported feeling otherwise well. Clinically, large brownish, slightly atrophic plaques were seen the torso suggestive of either morphea granulomatous condition. Histopathologic examination revealed an increase in interstitial histiocytes infiltrating between...