We report a familial case of keratoconus with corneal granular dystrophy. The mother and first son have both keratoconus and corneal granular dystrophy and the second son has keratoconus alone. The keratoconus in this family is thought to be an autosomal dominant or an X-linked inheritance pattern. Granular dystrophy is an autosomal dominant inheritance. This familial case suggests that the gen...

Most pedigrees of Aarskog's faciodigitogenital syndrome have suggested X linked inheritance. However, sex influenced autosomal dominant inheritance is also a possibility in some families. We describe an Arab family of normal consanguineous parents with five children (three males and two females) with some features of Aarskog syndrome in addition to some unusual hair changes. The possibility tha...

Genetics is complex and challenging due to the requirement of many basic biological concepts. In order to aid in the understanding of the Chi-squared test used in genetics, we have developed a statistical software tool on Mendelian and Xlinked Inheritance using the Java NetBeans IDE. The software tool guides the user through the Chi-squared test for monohybrid, dihybrid and X-linked (sex-linked...

Hereditary spastic paraparesis (HSP) or the Strümpell-Lorrain syndrome is the name given to a heterogeneous group of inherited disorders in which the main clinical feature is progressive lower limb spasticity. Before the advent of molecular genetic studies into these disorders, several classifications had been proposed, based on the mode of inheritance, the age of onset of symptoms, and the pre...

Hereditary spastic paraplegia (HSP) is a group of neurodegenerative diseases with genetic and clinical heterogeneity characterized by spasticity weakness the lower limbs. It includes four inheritance forms: autosomal dominant (AD), recessive (AR), X-linked inheritance, mitochondrial inheritance. To date, more than 82 gene loci have been found to cause HSP, SPG15 ( ZFYVE26 ) one most common here...

STUDY DESIGN A genomic screen and statistical linkage analysis of a large sample of families with individuals having idiopathic scoliosis was performed. OBJECTIVES To identify an X-linked susceptibility locus involved in the expression of familial idiopathic scoliosis. SUMMARY OF BACKGROUND DATA A large sample of families with individuals having idiopathic scoliosis (202 families; 1198 indi...

Alport syndrome is an inherited disease characterized by progressive renal failure, hearing loss, and ocular abnormalities. Inheritance is X-linked (85%) or autosomal recessive (15%). Many renal physicians think of Alport syndrome as primarily affecting men. However, twice as many women are affected by the X-linked diseases. Affected women are commonly undiagnosed, but 15%-30% develop renal fai...

We investigate the separation between types and classes by putting to use a special feature of Java regarding classes, interfaces and inheritance. We propose an original method which, from a single inheritance class hierarchy, extracts a multiple inheritance interface hierarchy, which contains all the types of the original hierarchy, each class being linked to the interface representing its typ...

INTRODUCTION The purpose of this research is genealogy examination of three generation of bipolar mood disorder Type I patients. METHODS Patients selected using Poisson sampling method from 100 patients with bipolar mood disorder Type I, referring to a psychiatric center of Amir Kabir Hospital of Arak, Iran. Examine issues such as physical ailments, psychological review of living and deceased...

We investigated the pattern of inheritance of maternal meiotic errors responsible for a high frequency of triploid progeny in a selected line of chickens. For the genetic analysis, F1 and backcross populations were produced from crosses between normal diploid individuals of the triploidy line and a control line. Triploid embryos were produced by 35% and 67% of reciprocal F1 females and by 24% a...