Vibrio cholerae is a diarrheal pathogen that induces accumulation of lipid droplets in enterocytes, leading to lethal infection of the model host Drosophila melanogaster. Through untargeted lipidomics, we provide evidence that this process is the product of a host phospholipid degradation cascade that induces lipid droplet coalescence in enterocytes. This infection-induced cascade is inhibited ...

G aining weight is associated with diabetes risk (1–3). It may be, however, that gaining lipid is associated more specifically with the development of insulin resistance, pancreatic exhaustion, and diabetes. According to a current pathophysiological model, when available fuels exceed the adipose tissue’s capacity for buffering and safe storage, lipid will be ectopically deposited in nonadipose ...

The bioactive principal, rotenoid, from the roots of Boerhaavia diffusa collected from various locations of NCT Delhi was extracted using organic solvents and determined with HPLC and compared with the standard isoflavenoid (rotenone). Six locations were selected for the study: Tuglaqabad, Dhaulakuan, Ridge area (Delhi University, North Campus), Nangloi, Saidulajab, Jawaharlal Nehru University ...

Background Microalgae are uniquely advantageous organisms cultured and harvested for several value-added biochemicals. A majority of these compounds are lipid-based, such as triacylglycerols (TAGs), which can be used for biofuel production, and their accumulation is most affected under nutrient stress conditions. As such, the balance between cellular homeostasis and lipid metabolism becomes mor...

BACKGROUND Ionic liquid (IL) pretreatment has emerged as a promising technique that enables complete utilization of lignocellulosic biomass for biofuel production. However, imidazolium IL has recently been shown to exhibit inhibitory effect on cell growth and product formation of industrial microbes, such as oleaginous microorganisms. To date, the mechanism of this inhibition remains largely un...

The present study was undertaken to determine oxidative/nitrosative stress in aqueous humor of alloxan-induced hyperglycemic rabbits and to investigate the effects of two oral antidiabetic drugs, pioglitazone from peroxisome proliferator-activated receptor gamma (PPARγ) agonists and repaglinide from nonsulfonylurea K(ATP) channel blockers. Ascorbic acid (AA), glutathione (GSH), total antioxidan...

The obese first degree relatives of type 2 diabetics are more prone to develop diabetes mellitus in later life. Having one parent with carries 1.6 fold and both the parents (T2DM) has 3.2 higher risk developing T2DM. Lipid accumulation product (LAP) is a simple reliable index central lipid accumulation. It combines waist circumference triacyglycerols. Studies have revealed that LAP better indic...