MicroRNAs has been shown to regulate lipogenesis in liver. The aim of the present study was to investigate whether the effects of resveratrol (RSV) on lipogenesis is associated with the changes in the expression of two miRNAs (miR-107 and miR-10b) that regulate lipogenic pathways. 30 wild type C57BL/6j male mice were randomly fed three diets: a standard chow diet (ND), a high fat diet (HFD, 60%...

Insulin drives the global anabolic response to nutrient ingestion, regulating both carbohydrate and lipid metabolism. When insulin resistance occurs in Type 2 Diabetes Mellitus, dysregulation of both of these processes ensues, resulting in hyperglycemia and lipid abnormalities. One of the most prevalent morbidities associated with insulin resistance is the abnormal accumulation of triglycerides...

OBJECTIVE To test the effects of novel oral hypoglycemic agent A-4166 on lipolysis and lipogenesis in adipocytes from normal rats and non-obese, hypertriglyceridemic, insulin resistant and hypertensive rats (HTG) fed basal or high fat diet. METHODS Adult male Wistar rats and hereditary HTG rats (from our own colony) were used. They were fed either basal or high fat diet for three weeks. On th...

In recent years there has been increasing appreciation of the metabolic activities that occur in the skin. The concept that the skin may manufacture the complex substances necessary to perform its function is gaining increasing support. In the category of lipids it seems possible that the skin itself synthesizes from other substances the fats necessary for the epidermal "barrier," the protectiv...

The time courses of restoration of fructose 2,6-bisphosphate (Fru-2,6-P2) concentrations and rates of lipogenesis after chow re-feeding were correlated with glycogen concentrations and rates of glycogen synthesis in livers of 48 h-starved euthyroid and hyperthyroid rats. Although a regulatory function for glycogen in the regulation of Fru-2,6-P2 concentrations was excluded, an inverse relations...

and TAG almost to values noted in control rats. These changes were associated with strong decline in SCD1, FAS and ACC protein levels. Additionally, the level of carnitine palmitoyltransferase 1, a key enzyme involved in regulation of fatty acid betaoxidation, was substantially increased. Also the transcription factor associated with oxidation, peroxisome proliferators-activated receptor-alpha,...

1. A single glucose meal stimulated the incorporation of acetate into fatty acids in liver slices. If the glucose was added in vitro, it had no effect. Fructose and glycerol in vitro markedly stimulated fatty acid synthesis from acetate. Fructose and glycerol probably by-passed a rate-controlling reaction between glucose and triose phosphate. This reaction may have been stimulated by glucose ad...