abstract   background: irregular working hours, including night work and shift work, have been found to be associated with alteration in various levels of biochemical factors. and some studies have showed association between shift work and blood biochemical disturbances in blood. in this epidemiological study we investigated, whether regular schedule of working hours can minimize the associated...

probiotic products highly affect the health of consumers by reducing the risk of heart attacks and improving the desirable microflora in the intestinal tract. in this study the effect of yogurt (500g/d for 3 wk) enriched with either bifidobacterium bifidum or lactobacillus acidophilus on the level of cholesterol, low density lipoprotein (ldl) and high density lipoprotein (hdl) of serum and ...

because the ingestion of some types of dietary fibers has been shown to influence on the lipid and lipoprotein levels, it is possible that chitosan influences on lipid metabolism. in the present study, the effects of chitosan on the serum, liver lipid and lipoprotein concentrations in rat were investigated. serum lipid level in the treatment groups were decreased compared to that of the control...

Few studies have investigated the role of elevated lipoprotein-associated phospholipase A2 (Lp-PLA(2)) with stroke risk, and those that have are based on small numbers of strokes. No study has evaluated the effect of hormone therapy use on the association of Lp-PLA(2) and stroke. We assessed the relationship between Lp-PLA(2) and the risk of incident ischemic stroke in 929 stroke patients and 9...

We investigated effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and its major metabolites, M2 and M4, on CuSO4-induced low-density lipoprotein (LDL) oxidation and cholesteryl ester accumulation in mouse peritoneal macrophages. All the test compounds inhibited LDL oxidation, and M2 had the most potent effect comparable to vitamin E. When LDL was pre...

The influence of different fibrates on apolipoprotein metabolism was investigated. Administration of fenofibrate provoked a dose-dependent decrease in plasma cholesterol concentration that was already evident after 1 day. Intestinal apolipoprotein (apo) A-I and apo A-IV mRNA levels remained fairly constant. In contrast, liver apo A-I, apo A-II, and apo A-IV mRNA levels decreased in a dose-depen...