Cardiovascular disease is one of the leading cause of mortality in the US and especially, coronary artery disease increases with an aging population and increasing obesity. Currently, bypass surgery using autologous vessels, allografts, and synthetic grafts are known as a commonly used for arterial substitutes. However, these grafts have limited applications when an inner diameter of arteries i...

A microfluidic bioreactor for cell co-culture has been developed to study the cytotoxicity of xenobiotics in multiorgan interaction models. In this paper, we investigate the drug metabolism of ifosfamide, an anticancer drug, in liver and its impact on kidney. HepG2/C3A (liver) and MDCK (kidney) cells are cultured in two separate PDMS chambers connected by a perfusion loop mimicking blood flow. ...

Twenty years of Italian outdoor investigations on closed photobioreactors are discussed in this review. Many photobioreactor designs have been projected; some have been built, tested and patented. The Italian research approach from tubular (single tube and traditional loop) to flat and column and again to tubular photobioreactors (coil and loops) has improved microalgal yield. It increased from...

Background Current in vitro and animal tests for drug development are failing to emulate the organ complexity of the human body and, therefore, to accurately predict drug toxicity. In this study, we present a self-contained, bioreactor based human in vitro tissue culture test system aiming to support predictive substance testing at relevant throughput. We designed a microcirculation system inte...

Growing hairy roots in bioreactors has proven challenging. Here we summarize the recent work using a novel bioreactor, the mist reactor, for the culture of hairy roots from many plant species. Compared to most liquid-phase bioreactors, this gasphase bioreactor offers a completely different environment for growing roots. Design, modeling, and some of the unique engineering aspects inherent to mi...

Objectives: The aim of this study was to assess the effects of different orthodontic vertical loop height and design on its force characteristics at different amount of loop activation by means of finite element method (FEM) analysis. Materials andMethods: Four 3D FEM models were designed of double vertical open loop (DVOL) and double vertical helical open loop (DVHOL) each of them in two heigh...

The mathematical model of the integrated process of mercury contaminated wastewater bioremediation in a fixed-bed industrial bioreactor is presented. An activated carbon packing in the bioreactor plays the role of an adsorbent for ionic mercury and at the same time of a carrier material for immobilization of mercury-reducing bacteria. The model includes three basic stages of the bioremediation ...

In this work the Computational Fluid Dynamics simulation of a stirred bioreactor purposely designed for the production of hydrogen from organic wastes fermentation is presented. The bioreactor is a vortex-ingesting, dual impeller, mechanically-agitated vessel equipped with a central draft tube. Due to the geometrical and physical complexity, the selected reactor offers a very challenging benchm...

Liquid sloshing is a common phenomenon in the transporting of liquid tanks. Liquid waves lead to fluctuating forces on the tank wall. If these fluctuations are not predicted or controlled, they can lead to large forces and momentum. Baffles can control liquid sloshing fluctuations. One numerical method, widely used to model the liquid sloshing phenomena is Smoothed Particle Hydrodynamics (SPH)....