نتایج جستجو برای: liquisolid compacts
تعداد نتایج: 1458 فیلتر نتایج به سال:
چکیده سابقه و هدف: پتانسیل روش مایع به جامد (liquisolid comppcrs) جهت افزایش ویژگی های انحلال داروهای نامحلول در آب، در سال های اخیر مورد بررسی و به اثبات رسیده است. به تازگی استفاده از این روش در کنترل سرعت آزادسازی نیز مورد بررسی قرار گرفته است. در این مطالعه تأثیر پلیمرهای اودراجیت (eudragit) و hpmc (hydroxy prapyl methyl cellulose) بر کنترل رهش تئوفیلین (theophylline) از فرمولاسیون های مختل...
Department of pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. ______________________________________________________________________ ABSTRACT Poorly water-soluble drugs involve many difficulties in the development of pharmaceutical dosage forms for oral delivery systems due to their low bioavailability. Therapeutic effectiveness of a drug depends upon the bioavailabilit...
Introduction: The potential of combining liquisolid and co-grinding technologies (liquiground technique) was investigated to improve the dissolution rate of a water-insoluble agent (glibenclamide) with formulation-dependent bioavailability. Methods: To this end, different formulations of liquisolid tablets with a wide variety of non-volatile solvents contained varied ratios of drug: solvent and...
Abstract Purpose The classic liquisolid technique is used to enhance the dissolution rate of poorly water-soluble drugs, but in some cases, it impossible reach desired using this alone. Therefore, a novel approach combination ball milling and technology was investigated improve for celecoxib. Methods First, celecoxib dispersed liquid vehicle (PEG 200), then ground mill 3 h. Other excipients, in...
This study was carried out to evaluate the absorption characteristics of experimentally developed hydrochlorothiazide liquisolid tablets using six male beagle dogs. Comparison with reference commercial tablets was made. As no bibliographic data were found for the pharmacokinetic parameters of the drug in dogs, an intravenous drug administration was included in the study. The drug was administer...
سابقه و هدف: پتانسیل سیستم های مایع به جامد (liquisolid) جهت افزایش ویژگی های انحلال داروهای نامحلول در آب، در سال های اخیر مورد بررسی قرار گرفته و به اثبات رسیده است. در این مطالعه تاثیر حلال غیر فرار گلیسرین بر فرمولاسیون های مختلف از قرص های مایع به جامد ایندومتاسین مورد بررسی قرار گرفت.مواد و روش ها: در این پژوهش از آویسل (به عنوان حامل) و سیلیکا (به عنوان عامل پوشاننده) با نسبت 20:1 استفاد...
The present research aimed to improve the dissolution rate and bioavailability of curcumin using the potential of liquisolid technology. Twelve drug-loaded liquisolid systems (LS-1 to LS-12) were prepared using different vehicles (PEG 200, PEG 400 and Tween 80) and curcumin concentrations in vehicle (40%, 50%, 60% and 70%, w/w). The carrier [microcrystalline cellulose (MCC) PH102] to coat (Aero...
In this study; iron based powder metal (PM) bushing compacts were sintered via medium frequency induction heating system. Iron based powders were mixed with 2 wt.% copper (Cu), 0.3 wt.% carbon (C) and 1 wt.% zinc stearat (Zn-st) via V-Type mixer. PM compacts were sintered by 2 different sintering processes. One of them was conventional sintering method other was medium frequency induction sinte...
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