BACKGROUND The prolonged time course of Huntington's disease (HD) neurodegeneration increases both the time and cost of testing potential therapeutic compounds in mammalian models. An alternative is to initially assess the efficacy of compounds in invertebrate models, reducing time of testing from months to days. METHODOLOGY/PRINCIPAL FINDINGS We screened candidate therapeutic compounds that ...

This study examined choline augmentation of lithium for rapid-cycling bipolar disorder. Choline bitartrate was given openly to 6 consecutive lithium-treated outpatients with rapid-cycling bipolar disorder. Five patients also underwent brain proton magnetic resonance spectroscopy. Five of 6 rapid-cycling patients had a substantial reduction in manic symptoms, and 4 patients had a marked reductio...

Emission of gas at charged states of lithium ion batteries (LIBs) is a significant problem because it causes swelling and deformation of LIBs. In this study, the gas generation mechanism is investigated and preventative measures are developed. Decomposition of the electrolyte solution related to residual lithium compounds on the surface of LiNi0.5Co0.2Mn0.3O2 (NCM523) and to the structural chan...

Sulfur is a very promising cathode material for rechargeable energy storage devices. However, sulfur cathodes undergo a noticeable volume variation upon cycling, which induces mechanical stress. In spite of intensive investigation of the electrochemical behavior of the lithiated sulfur compounds, their mechanical properties are not very well understood. In order to fill this gap, we developed a...

Abstract We studied the electronic structure of lithium metal, fluoride, and spodumene using density functional theory. performed calculations total, local partial states, x‐ray emission spectra. observed changes in Li K spectra shape energy position due to chemical composition modification. also outline possible interferences between bands.

background: lithium has been the treatment of choice for bipolar disorder (bd) for many years. although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. objective: the aim was to investigate the possible involvement of nitric oxide (no) in modulatory effect of lithium on penile erection (pe). we fur...