A female dog of the Shar Pei breed, aged 28 months, was euthanised due to familial shar pei fever with amyloidosis. Microscopic and ultrastructural analyses demonstrated the dog to be affected by acute pancreatitis as an outcome of renal amyloidosis and morphological lesions occurring in the liver. The presented case report depicts the microscopic and ultrastructural pattern of the dog pancreas...

Amyloidosis is a rare disorder caused by deposition of amyloid fibrils in various tissues causing structural and functional defects. Depending upon organs involved, it may be categorized as localized or systemic. Systemic amyloidosis involves multiple organs where some organs are affected more commonly than others. Diagnosis is often challenging as in a 76-yearsold female described here who pre...

The amyloidoses are a group of protein-misfolding disorders characterized by the accumulation of amyloid fibrils formed from a variety of proteins. Currently, twentyeight different kinds of human and animal proteins, in intact or fragmented forms, have been found to be associated with pathological disorders such as Alzheimer’s disease, type II diabetes, prion diseases, dialysis-related amyloido...

amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different organs, where it usually causes some type of dysfunction. its cause is unknown. five different types of amyloidosis have been described according to the underlying disease; immunoglobulin amyloidosis, familial amyloidosis, senile systemic amyloidosis, secondary amyloidosis and hemodialysis-associated am...

Two hundred and thirty-three patients with renal amyloidosis were studied in an attempt to identify the incidence and pattern of the disease in northern India. The incidence of amyloidosis was 1.01% of 6431 post-mortems and 8.4% of 1980 renal biopsies from patients who presented with clinical evidence of glomerular disease. Two hundred and three patients (87.1%) had secondary amyloidosis, 22 (9...

An 80-year old woman complained of a 1-month history of dry cough. Bronchoscopy and tracheobronchial biopsy revealed tracheobronchial amyloidosis. Compted tomography scan showed narrowing of the trachea with intraluminal nodularity. Whole body and single photon emission computed tomography Tc pyrophosphate scan revealed diffuse uptake in the tracheobronchial tree, liver, and myocardium — with a...

A patient with end-stage renal disease undergoing chronic hemodialysis presented with disseminated systemic primary amyloidosis without evidence of ?2microglobulin deposition. Multiorgan involvement proved by biopsy was present in breast, lymph nodes, gastric mucosa, and bone marrow. Imaging studies and biochemical testing revealed evidence suggesting involvement of other organ systems, includi...

primary localized amyloidosis of eyelid is a localized type of amyloidosis without evidence of systemic involvement. we report a 75-year-old man suffering of unilateral (left) ptosis due to upper eyelid mass with bony consistency. eye examination revealed upper lid mass attached to tarsus. no ocular infection or inflammation was found. pathologist reported diffuse distribution of eosinophilic h...

Involvement of the abdominal organs has variable presentations mostly without specific findings. The objective of this pictorial essay was to illustrate the computed tomography and magnetic resonance imaging (MRI) findings of abdominal involvement in systemic amyloidosis. Heterogeneous appearance of the liver, periportal involvement, diffuse low signal intensity of spleen on T2-weighted MRI, an...

familialmediterranean fever (fmf) is a hereditary syndrome characterized by recurrent attacks of fever and serositis. liver involvement in fmf has been reported in association with amyloidosis or rarely with vasculitis.in this report, a 32 year-old man with recurrent attacks of fever, abdominal pain and arthralgia is described who had moderate increase in liver transaminases only during disease...