Background and objectivesMethylenetetrahydrofolate Reductase (MTHFR) is the critical enzyme in folate 1-carbon metabolism. MTHFR polymorphisms may result increased homocysteine levels, be associated with abnormal lipid metabolism liver. This study aims to explore association between gene of rs1801131 rs1801133 susceptibility nonalcoholic fatty liver disease (NAFLD) coronary artery (CAD).

INTRODUCTION Liver enzyme abnormalities are common in HIV patients, and the prevalence varies across the nations. In Nepal, however, prevalence of liver enzyme disorder and the spectrum of these populations are lacking. OBJECTIVE The present study sheds light on prevalence and clinical spectrum of liver disease in Nepalese HIV-sero-positive patients. METHODS This cross-sectional study was c...

Pediatric obesity has increased dramatically all over the world and nonalcoholic fatty liver disease (NAFLD) is one of the most frequent complications associated with excess adiposity. NAFLD causes serum transaminase elevation and liver disease, which could end up in fibrosis, cirrhosis and eventually hepatocellular carcinoma. NAFLD seems to be associated with the metabolic complications of obe...

Objective(s): Alteration in drug metabolism is very likely in diabetes mellitus. This study assessed changes in CYP2C19 enzymatic activity in the liver using omeprazole as a probe in the animal model of type II diabetes (T2DM) before and after treatment with metformin and cinnamon.Materials and Methods: Twenty-eight male Wistar rats were...

Poly(ADP-ribose) polymerase activity was determined in liver nuclei isolated from partially hepatectomized rats and was compared with the activity in sham-operated animals. There were minor, time-dependent variations in enzyme activities, which, however, do not seem to be related to DNA formation or mitosis. When adult and neonatal rat liver nuclei were compared, again very similar polymerase a...

Liver damage is the most common complication of anti-tuberculosis drugs, but there is currently no standard prevention for it. The main purpose of this study is to determine the effectiveness of Ziziphus jujuba (Z. jujuba) syrup on the prevention of liver enzyme disorder in TB patients. This study was a protocol for randomized controlled trial. 48 patients were included in the study who were r...

liver is a major organ of the body which can be exposed to various chemicals, drugs, and many other xenobiotics such as bromobenzene. bromobenzene must be converted to its active metabolites to produce liver and kidney toxicity. livergol is an herbal product which contains silymarin. the objective of this study was to find out the protective effect of livergol against liver toxicity induced by ...

Serum liver tests are important but often problematic in evaluating patients with and without symptoms of hepatic disease. The common term "liver function tests" is misleading because most tests used in clinical practice measure hepatocellular damage not function. True liver function tests are those that measure synthesis of proteins made by the liver (albumin, clotting factors) or the liver's ...

Background: Fasciola hepatica is a genus of the trematodes which mainly affects the liver of sheep and these livestock are accidentally infected by eating plants or drinking water contaminated with the metacercariae of this parasite. These parasites can cause considerable economic damage by destroying the liver and bile ducts. OBJECTIVES: The aim of this study was to evaluate the role of ultras...