OBJECTIVE—Ectopic lipid storage in muscle (intramyocellular lipids [IMCL]) and liver (hepatocellular lipids [HCL]) coexists with impaired myocellular flux through ATP synthase (fATPase) in certain cohorts with increased risk of type 2 diabetes. Because women with a history of gestational diabetes (pGDM) have elevated ectopic lipids and diabetes risk, we tested whether deteriorated energy metabo...

Purpose: Aging is related to multiple and systemic dysfunctions in the body, accompanied by metabolic disorders oxidative stress. Although studies are revealing role of endoplasmic reticulum (ER) stress aging-related pathologies, this relationship has not been fully elucidated. In study, it was aimed reveal changes liver function, plasma lipids, markers due aging gender, investigate how these p...

The effects of incorporating cyanoglucoside extracts from yam or dasheen into the diet of streptozotocin-induced diabetic Wistar rats were studied for four weeks. Intestinal lipase activity, and plasma glucose and lipid levels were determined. Also, liver total lipids, activities of ATP citrate lyase, pyruvate kinase and 6-phosphogluconate dehydrogenase were assessed. Dasheen extract significan...

It has previously been shown that when the molecular species specificity of rat liver Golgi CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase was determined, using as the substrate lactosylceramide (LacCer) incorporated into liposomes prepared with rat liver Golgi lipids, the enzyme showed a pronounced variation in activity towards the various molecular species of LacCer (J. ...

The effect of ingestion of saline, glucose, and ethanol (isocaloric with the glucose) on the mobilization of radiopalmitate from epididymal fat prelabeled in vivo and the incorporation of the mobilized label into liver lipids was investigated in rats. The mobilization of radiopalmitate from epididymal fat and the incorporation of the mobilized label into liver triglyceride were most markedly el...

A method of employing high-resolution mass spectrometry in combination with in vivo metabolite deuterium labeling was developed in this study to investigate the effects of alcohol exposure on lipid homeostasis at the white adipose tissue (WAT)-liver axis in a mouse model of alcoholic fatty liver. In order to differentiate the liver lipids synthesized from the fatty acids that were transported b...

The thought of using branched-chain amino acids (BCAA) in the prevention and treatment certain disorders is becoming increasingly popular. Individual BCAA use has been associated with improving glucose tolerance liver disease. Previous studies have cited improvements metabolism a single dose L-isoleucine (ILE). However, it still unclear whether chronic consumption ILE any direct benefit. object...

This study aims to evaluate the benefit of combined administration of sodium molybdate with atorvastatin in management of hyperlipidemia. Hyperlipidemic male Serian golden hamsters were administered either atorvastatin (40 or 80 mg/kg, p.o.) sodium molybdate (100 mg/kg, p.o.) or combination of atorvastatin (40 mg/kg, p.o.) with sodium molybdate (100 mg/kg, p.o.) for 30 consecutive days. Blood l...

Serum lipids, lipids (cholesterol, triglycerides and phospholipids) and apo-A in d.>1. 063 fraction, HDL2, HDL8 and VHDL of 10 normal subjects and 34 patients with chronic liver diseases (chronic aggressive hepatitis 2A and 2B, and liver cirrhosis in the compensated and decompensated stages) were analyzed. The analysis of d.>1. 063 and its subfractions (HDL2, HDL8 and VHDL) was achieved by rela...