Ixabepilone (Ixempra) is a member of a new class of cytotoxic agents, the epothilones. Epothilones promote tubulin polymerization in vitro and demonstrate antitumor activity. This article reviews the preclinical and clinical data that have led to the approval of ixabepilone for patients with locally advanced or metastatic breast cancer for whom anthracycline and taxane treatments have failed.

Improvements in strength and setting time of Portland cements (PC) are needed to enhance their performance as endodontic and load bearing materials. This study sought to enhance the compressive strength and setting time of a PC by adding one of the following additives: 20% and 30% poly-methylmethacrylate (PMMA), 20% and 30% irregular and spherical amalgam alloys, and 10% CaCl(2). The control co...

This Book Review is brought to you for free and open access by the Tampa Library at Scholar Commons. It has been accepted for inclusion in Genocide Studies and Prevention: An International Journal by an authorized administrator of Scholar Commons. For more information, please contact [email protected]. Recommended Citation Powell, Christopher Ph.D. (2015) "Book Review: Warning Signs of Gen...

The purpose of this study was to determine the effects of age, load amount and load symmetry on lower extremity kinematics during carrying tasks. Forty-two participants in four age groups (8-10 years, 12-14 years, 15-17 years and adults) carried loads of 0%, 10% and 20% body weight (BW) in large or small buckets unilaterally and bilaterally. Reflective markers were tracked to determine total jo...

BACKGROUND Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses and mycobacterial load remains unclear. We hypothesised that, in a HIV-prevalent high burden setting, the magnitude of mycobacterial antigen-specific and non-specific T-cell IFN-γ responses would correl...

Distributed file systems are key building blocks for cloud computing applications supported the Map Reduce programming paradigm. In such file systems, nodes at the same time serve computing and storage functions; a file is partitioned off into variety of chunks allotted in distinct nodes so Map Reduce tasks are often performed in parallel over the nodes. However, in a cloud computing setting, f...

Students of social movements have long struggled with the question how relatively abstract political opportunities, such as elite divisions, affect unorganized activists without much knowledge of politics. We argue that the relationship between institutional opportunities and decisions to mobilize may take the form of trickle-down politics. In this view activists are affected by political oppor...

Problem definition. We consider the classical scheduling problem of maximizing the minimum machine load on parallel machines. In this setting we are given a set of jobs J , a set of machines M to process the jobs and a processing time pj for each job j ∈ J . For a given assignment of jobs to machines, the load of a machine i is defined as the sum of the processing of jobs assigned to i. Our obj...