The peptide hormone ghrelin is the only known protein modified with an O-linked octanoyl side group, which occurs on its third serine residue. This modification is crucial for ghrelin's physiological effects including regulation of feeding, adiposity, and insulin secretion. Despite the crucial role for octanoylation in the physiology of ghrelin, the lipid transferase that mediates this novel mo...

Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin's physiological effects and is catalyzed by the polytopic enzyme ghrelin O-acyltransferase (GOAT). The aim of this study was to characterize GOAT in a teleost model, goldfish (Carassius auratus). First, the full-length cDNA sequence was obtained by RT-PCR and rapid ...

The status, economics and prospects of commercialization of goat production in the country have been analyzed using primary data from 18 commercial goat farms in different states. It has been revealed that several large and progressive farmers, businessman and industrialists have adopted commercial goat farming. The entry of large farmers, who have better access to technical knowledge, resource...

West African Dwarf (WAD) goats are extremely important in the rural village economy of West Africa, but still little is known about their biology, ecology and capacity to cope with gastrointestinal nematode (GIN) infections. Here, we summarise the history of this breed and explain its economic importance in rural West Africa. We review recent work showing that Nigerian WAD goats are highly tryp...

Ghrelin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-deprived stomach. Serine-3 of ghrelin is acylated with an eight-carbon fatty acid, octanoate, which is required for its endocrine actions. Here, we identify GOAT (Ghrelin O-Acyltransferase), a polytopic membrane-bound enzyme that attaches octanoate to serine-3 of ghrelin. Analysis of the mouse genome revealed ...

BACKGROUND Traditional approaches for generating goat pluripotent stem cells (iPSCs) suffer from complexity and low preparation efficiency. Therefore, we tried to derive goat iPSCs with a new method by transfecting exogenous Oct4, Sox2, Klf4 and c-Myc mRNAs into goat embryonic fibroblasts (GEFs), and explore the mechanisms regarding the transcription regulation of the reprogramming factors in g...

Large areas of South Africa are only suitable for animal production off natural veld, and it is in these ecosystems that the goat has the biggest potential. Developing this potential, however, will require a co-ordinated and multi-functional approach where subject matter specialists work together as a team. Past research and development initiatives in South Africa have concentrated largely on t...

AIM The study was undertaken to find out the gross composition, nitrogen distribution, and selected mineral content in Surti goat milk, and its comparison was made between cow and buffalo milk. MATERIALS AND METHODS Goat milk samples of Surti breed and buffalo milk samples were collected during the period from July to January 2014 at Reproductive Biology Research Unit, Anand Agricultural Univ...

BACKGROUND AND PURPOSE Optical coherence tomography (OCT) is a light-based imaging technique suitable for depiction of thin tissue layers such as articular cartilage. Quantification of results and direct comparison with a reference standard is needed to confirm the role of OCT in cartilage evaluation. MATERIALS AND METHODS Goat talus articular cartilage repair was assessed quantitatively with...

This study was conducted in the Ruminants Research Station, Office of Agricultural Research/ Ministry Agriculture- Iraq to detect CYP17 gene polymorphisms Local and Shami goat, as well establish if SNPs could be associated with some productive reproductive traits such total milk yield (TMY) its components, addition which included litter size fertility. An important single nucleotide (SNPs) (G22...