نتایج جستجو برای: locally advanced cervical carcinoma

تعداد نتایج: 749643  

Journal: :The New England journal of medicine 2012
Aleksandar Sekulic Michael R Migden Anthony E Oro Luc Dirix Karl D Lewis John D Hainsworth James A Solomon Simon Yoo Sarah T Arron Philip A Friedlander Ellen Marmur Charles M Rudin Anne Lynn S Chang Jennifer A Low Howard M Mackey Robert L Yauch Richard A Graham Josina C Reddy Axel Hauschild

BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first-in-class, small-molecule inhibitor of the hedgehog pathway, showed a 58% response rate among pati...

ابراهیم عصمتی, , بی‌تا کلاغچی, , فرناز آموزگار هاشمی, ,

Background: Carcinoma of the uterine cervix is the sixth most common malignant neoplasm in women. Early stage diagnosis of uterine cervix carcinoma increases the cure rate of disease. Radiotherapy, with or without concurrent chemotherapy, is one of the most effective treatment modality in cervical carcinoma. After radiotherapy, accurate and regular follow-up results in early diagnosis and effec...

Journal: :Canadian Medical Association Journal 2019

Journal: :Cochrane Database of Systematic Reviews 2018

Journal: :archives of breast cancer 0
saeed arefanian department of surgery, washington university, st. louis, usa neda mehradad breast disease research group, breast cancer research center, tehran, iran shahpar haghighat breast disease research group, breast cancer research center, tehran, iran safa najafi breast disease research group, breast cancer research center, tehran, iran mandana ebrahimi breast disease research group, breast cancer research center, tehran, iran asiie olfatbakhsh breast disease research group, breast cancer research center, tehran, iran

background: inflammatory breast cancer (ibc), a subgroup of locally advanced breast cancer (labc), is diagnosed based on clinical findings, and seems to be different from other types of labc. the purpose of this study was to compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory labc patients at breast cancer research center (bcrc), tehran, iran. meth...

Journal: :JAMA dermatology 2014
Gefei A Zhu Uma Sundram Anne Lynn S Chang

IMPORTANCE Vismodegib is a Hedgehog signaling pathway inhibitor recently approved by the US Food and Drug Administration for advanced basal cell carcinoma. We present 2 cases of clinically significant squamous cell carcinoma within the tumor bed of locally advanced basal cell carcinoma found during vismodegib treatment. OBSERVATIONS The first case is that of a patient with locally advanced ba...

Journal: :International Journal of Radiation Oncology*Biology*Physics 2018

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