BACKGROUND Gamma-hydroxybutyrate is currently used to promote nighttime sleep in the treatment of narcolepsy; however, it is also a drug of abuse ("Liquid Ecstasy") associated with a withdrawal syndrome with anxiety features. Of interest, the activity of locus coeruleus neurons is a reflective index of these above mentioned behavioral states. METHODS Using in vivo extracellular unitary record...

Through a widespread efferent projection system, the locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. Initial studies provided critical insight into the basic organization and properties of this system. More recent work identifies a complicated array of behavioral and electrophysiological actions that have in common the facilitation of processi...

The effect of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on electroencephalographic activity (EEG) was studied in the model of chronic focal epilepsy induced by intracortical injection of FeCl3 in the rat. EEG activity was recorded from the epileptogenic focus (ipsilateral and contralateral) in chronic experiments before and after DSP-4 treatment. In some ...

The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and stimulation studies demonstrated potential for PFC-LC interactions; however, it unknown what types of PFC affect LC. Here, we show that transient increases high ? power associated changes unit-pair synchrony are a sign top-down over

noradrenaline release.8.9 While clonidine and the opiates have similar effects on the locus coeruleus, clonidine appears to exert specific effects through non-opiate, alpha-2 adrenergic receptors. 6, These data suggested that the opiate-withdrawal syndrome is due to increased noradrenergic neuronal activity in areas such as the locus coeruleus which are regulated both by alpha-2 adrenergic and ...

Introdução: A degeneração progressiva dos neurónios do Locus Coeruleus associada à diminuição de recetores adrenérgicos, alvos da Noradrenalina, conduz a uma função cerebral, provocando baixa resposta hemodinâmica e atividade neuronal. disfunção noradrenérgica pode, ainda, interromper capacidade monitorizar estímulos externos alterar o processo cognitivo atenção, como acontece na Doença Alzheim...