Long noncoding RNAs belong to a class of noncoding RNAs longer than 200 nucleotides with the epigenetic regulation potential. As a novel molecular regulator, lncRNAs are often dysregulated in various pathological conditions and display multiple functions in a wide range of biological processes. Given that recent studies have indicated that lncRNAs are involved in atherosclerosis-related smooth ...

Objective: Noncoding RNAs are emerging as important players in gene regulation and cardiovascular diseases. Their roles the pathogenesis of atherosclerosis not fully understood. The purpose this study was to determine role played by a previously uncharacterized long noncoding RNA, RP11-728F11.4, development mechanisms which it acts. Approach Results: Expression microarray analysis revealed that...

We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates...