Introdução: A infecção pelo papilomavírus humano (HPV) é a doença sexualmente transmissível (IST) mais comum em mulheres. Até os 50 anos de idade, cerca 80% da população feminina será exposta ao vírus. O desenvolvimento lesões precursoras do câncer colo útero está atrelado à persistência HPV, responsável por causar as intraepiteliais alto grau (HSIL). Outros fatores como o comportamento sexual ...

OBJECTIVE Continuous expression of E6- and E7-oncogenes of high-risk human papillomavirus (HPV) types is necessary for the development and maintenance of the dysplastic phenotype. The aim of the study was to determine the sensitivity and specificity of the APTIMA HPV mRNA assay (Hologic) in predicting future development of high-grade cervical intraepithelial neoplasia (CIN) among high-risk HPV-...

BACKGROUND Persistent infection with high-risk human papillomavirus (HPV) has been recognized as a major cause of cervical cancer. Distribution of HPV genotypes may differ according to the geographic region and the severity of the cervical lesion. Determining HPV genotypes' specific distribution is useful for HPV surveillance and control programs. However, little is known about the distribution...

BACKGROUND HPV DNA testing has been recently introduced as an adjunct test to cytology in the follow-up of patients after treatment for cervical lesions using the loop electrosurgical excision procedure (LEEP). The aim of this study was to evaluate the role of HPV testing in the detection of persistent or recurrent disease after LEEP in patients with cervical epithelial lesions in northern Thai...

To estimate the risk of human papillomavirus (HPV) infection for cervical malignancies, we conducted a case-control study in Japan. Abnormal cervical cell (366) and normal cell samples (1562) were tested for the presence of HPV DNA using a new PCR-based test (LCR-E7 PCR). When single HPV infections were considered, 26 different HPV types were identified in normal cervices and in low-grade squam...

BACKGROUND Human Papillomavirus (HPV) genotype distribution and co-infection occurrence was studied in cervical cytologic specimens from Murcia Region, (southeast Spain), to obtain information regarding the possible effect of the ongoing vaccination campaign against HPV16 and HPV18. METHODS A total of 458 cytologic specimens were obtained from two outpatient gynecological clinics. These inclu...

BACKGROUND The objective of this study was to investigate the expression of human papilloma virus (HPV) L1 capsid protein in abnormal cervical cytology with HPV16 infection and analyze its association with cervical histopathology in Korean women. MATERIAL AND METHODS We performed immunocytochemistry for HPV L1 in 475 abnormal cervical cytology samples from patients with HPV16 infections using...

The objective: a study the effect of complex hyaluronic acid with plant extracts and polyphenolic component on cell proliferation progression cervical carcinogenesis.Materials methods. 74 patients pathology (average age is 29.8 years) formed basic group were examined in clinic “Doctor Alex” (Kharkiv), 62 women them had diathermoconization, 12 – laser vaporization cervix. Histologically, high-gr...