We study two designs for a liquidity-saving mechanism (LSM), a queuing arrangement used with an interbank settlement system. We consider an environment where banks are subjected to liquidity shocks. Banks must make the decision to send, queue, or delay their payments after observing a noisy signal of the shock. With a balance-reactive LSM, banks can set a balance threshold below which payments ...

Lsm proteins are ubiquitous, multifunctional proteins that affect the processing of most RNAs in eukaryotic cells, but their function is unknown. A complex of seven Lsm proteins, Lsm2-8, associates with the U6 small nuclear RNA (snRNA) that is a component of spliceosome complexes in which pre-mRNA splicing occurs. Spliceosomes contain five snRNAs, U1, U2, U4, U5, and U6, that are packaged as ri...

Sm-like (Lsm) proteins are ubiquitous, multifunctional proteins that are involved in the processing and/or turnover of many RNAs. In eukaryotes, a hetero-heptameric complex of seven Lsm proteins (Lsm2-8) affects the processing of small stable RNAs and pre-mRNAs in the nucleus, whereas a different hetero-heptameric complex of Lsm proteins (Lsm1-7) promotes mRNA decapping and decay in the cytopla...

BACKGROUND Assessing liver fibrosis is traditionally performed by biopsy, an imperfect gold standard. Non-invasive techniques, liver stiffness measurements (LSM) and biomarkers [FibroTest(R) (FT)], are widely used in countries where they are available. The aim was to identify factors associated with LSM accuracy using FT as a non-invasive endpoint and vice versa. METHODS The proof of concept ...

BACKGROUND An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over...

The area under the curve (AUC) can be associated with the therapeutic or toxic effect of a drug. The limited sampling model (LSM) is an approach that is gaining popularity due to its simplicity for the estimation of AUC using 1-3 blood samples. The aim of the present simulation study was to compare the performance of LSM for various hypothetical drugs with that of the naive trapezoidal method (...

years from a general population attending a medical check-up. All subjects were submitted to medical examination and laboratory tests in addition to LSM, performed the same day by a single operator. Subjects with LSM values over 8 kPa were referred to a liver unit for further investigation. Subjects with missing data (n = 23), LSM failure (n = 51) or unreliable LSM values (n = 94) were not cons...

Automated generation of digital elevation models (DEMs) from high resolution satellite images (HRSIs) has been an active research topic for many years. However, stereo matching of HRSIs, in particular based on image-space search, is still difficult due to occlusions and building facades within them. Object-space matching schemes, proposed to overcome these problem, often are very time consuming...

In this paper, we present a variant of local search, namely the Life Span Method (LSM), for generic combinatorial optimization problems. The LSM can be seen as a variation of tabu search introduced by Glover [18, 19]. We outline applications of the LSM to several combinatorial optimization problems such as the maximum stable set problem, the traveling salesman problem, the quadratic assignment ...