The synthesis and secretion of progesterone in the corpus luteum are regulated by both endocrine and paracrine/ autocrine factors which affect the steroidogenic cells. Evidence suggests that these cells communicate via cell-cell junctional proteins, the connexins. Previously we have shown that connexin-43 is expressed in both human and baboon (Papio hamadryus anubis) corpora lutea, with differe...

BACKGROUND Mechanical endometrial injury prior to IVF has been suggested as a means to increase implantation rates by improving endometrial receptivity. However, the effects of endometrial injury in proliferative vs. luteal phase have not been studied before. This study aimed to explore whether endometrial injury in the proliferative phase of the preceding cycle before in vitro fertilization/em...

OBJECTIVE To investigate whether allopregnanolone, a neuroactive steroid involved in modulating behavioural and neuroendocrine functions, shows episodic secretion in eumenorrheic women, during the follicular and luteal phases of the menstrual cycle, and in women with stress-induced amenorrhea. PATIENTS Six eumenorrheic women and 14 women with hypothalamic amenorrhea were enrolled for the pres...

We previously reported that BRCA1/2-mutated fallopian tube epithelium (FTE) collected during the luteal phase exhibits gene expression profiles more closely resembling that of high-grade serous carcinoma (HGSC) specimens than FTE collected during the follicular phase or from control patients. Since the luteal phase is characterised by high levels of progesterone, we determined whether the expre...

Background: Progesterone (P) that is produced by the corpus luteum in response to stimulation by luteinizing hormone (LH) and human Chrionic Gondotropin (hCG) in luteal phase is essential for secretory transformation of endometrium that permits implantation .P not only supports endometrial development but also potentially sustains the survival of the embryo . Luteal phase dysfunction (LPD) is a...

Body temperature and sleep change in association with increased progesterone in the luteal phase of the menstrual cycle in young women. The mechanism by which progesterone raises body temperature is not known but may involve prostaglandins, inducing a thermoregulatory adjustment similar to that of fever. Prostaglandins also are involved in sleep regulation and potentially could mediate changes ...

OBJECTIVE The luteal phase after ovarian hyperstimulation for in vitro fertilization (IVF) is insufficient. Therefore, luteal phase supplementation is routinely applied in IVF. It may be postulated that premature luteolysis after ovarian hyperstimulation is due to supraphysiological steroid levels in the early luteal phase. In the present study, high doses of steroids are administered after the...

In this study the reproductive organs of adult and apparently healthy female Azarbaijan buffaloes werecollected after slaughter from abattoir. Through observation of the ovaries, the luteal and follicular phases ofeach buffalo were specified. A total number of 36 oviducts at follicular phase and 36 oviducts at luteal phasewere collected and 3 tissue samples were taken from 3 regions of infundib...

The cyclic changes of menstrual cycle alter the pharmacokinetics of levofloxacin. The effect of follicular and luteal phase on levofloxacin pharmacokinetics was studied in 15 healthy female volunteers taking a single dose of 500mg tablet on day 10 (follicular phase) and day 21 (luteal phase ). Levofloxacin levels in saliva samples at different time points were estimated by HPLC. Follicular phas...