an 11 year – old mixed female labrador was presented with two masses in trunk and neck. the tumoral masses were excised and sent for histopathological and immunohistochemical analyses. histopathological examination of masses revealed diffuse infiltration of small sized lymphoid cells in subcutaneous tissue which were intense around the blood vessels. more than 10% lymphoid cells were cd3 positi...

the production of murine monoclonal antibody (mab) has not yet been reported in iran. the present work describes for the first time the generation of several murine hybridoma clones secreting mabs directed against human leukocyte surface antigens. the secreted antibodies by hybridoma clones have been screened on different lymphoid and non-lymphoid tissues. results indicated that of seven hybrid...

Aims—To provide practical guidelines for the diVerentiation between benign and malignant focal lymphoid aggregates (lymphoid nodules) in routinely referred bone marrow trephine biopsies, using a synoptic approach including clinical data and histological workup. Methods—For easy identification of very small lymphoid infiltrates the chloroacetate esterase stain was applied as a screening procedur...

The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses. The development of these peripheral secondary lymphoid organs (SLO) occurs mainly in utero, while tertiary lymphoid structures can form in adulthood generally in response to persistent infection and inflammation. Regardless of...

The present paper reports a study of lymphoid tissue in lizards and describes some of the characteristics of their lymphoid tissue. Lymphoid tissue in other reptiles was studied in turtles by K o n d o (1937) and M or i (1941) and in snakes by Mori (1941), T a k a wa (1943) and K o t an i (1959). Recently, K i h a r a (1954) subdivided the lymphoid tissue, in general, into two : the subepitheli...

Stromal cell microenvironments within lymphoid tissues are designed to support immune cell homeostasis and to regulate ongoing immune responses to pathogens. Such stromal cell networks have been best characterized within lymphoid tissues including the spleen and peripheral lymph nodes, and systems for classifying stromal cell phenotypes and functions are emerging. In response to inflammation, s...

MicroRNAs profoundly impact hematopoietic cells by regulating progenitor cell-fate decisions, as well as mature immune effector function. However to date, microRNAs that regulate hematopoietic stem cell (HSC) function have been less well characterized. Here we show that microRNA-125b (miR-125b) is highly expressed in HSCs and its expression decreases in committed progenitors. Overexpression of ...

AIMS To provide practical guidelines for the differentiation between benign and malignant focal lymphoid aggregates (lymphoid nodules) in routinely referred bone marrow trephine biopsies, using a synoptic approach including clinical data and histological workup. METHODS For easy identification of very small lymphoid infiltrates the chloroacetate esterase stain was applied as a screening proce...

Studies on the role of the thymus in the adult have demonstrated its essential participation in lymphoid (2-4) and immunological (5, 6) recovery following total body x-irradiation. Subsequent investigations have suggested that the thymus acts indirectly (4, 7), probably by a humoral factor (8) as previously shown for lymphoid development during early postnatal life (9, 10). Although various att...