We investigated the capacity of murine T lymphocytes, isolated from various lymphoid organs of normal or antigen-primed donors, to produce IL-2 or IL-4 after activation with anti-CD3 or specific antigen. Our results established that T cells resident within lymphoid organs being drained by nonmucosal tissue sites (e.g., axillary, inguinal, brachial lymph nodes, or spleen) produced IL-2 as the pr...

It is commonly accepted that immune tolerance to self-antigens occurs in the thymus and secondary lymphoid organs. Despite presence of rich microenvironments non-lymphoid organs, such as skin gut, it currently unknown if self-tolerance actively maintained these tissues. We developed a novel technique induce genetic recombination only regulatory T cells (Tregs) reside skin. Cell lineage-tracing ...

Lymphoid follicles evolve in the perivascular connective tissue of many organs, including the thymuses, in NZB/Bl mice with hemolytic anemia. In previously published studies, these thymic follicles have been held to be causal in the autoimmune genesis of the hemolytic anemia. The present study contradicts this interpretation by demonstrating: (a) lymphoid follicles develop in the perivascular c...