Mycoplasma mobile glides on a glass surface in the direction of its tapered end by an unknown mechanism. Two large proteins, Gli349 and Gli521, were recently reported to be involved in glass binding and force generation/transmission, respectively, in M. mobile gliding. These proteins are coded tandemly with two other open reading frames (ORFs) in the order p123-gli349-gli521-p42 on the genome. ...

A group A Streptococcus (GAS) isolate, serotype M12, recovered from a patient with streptococcal toxic shock syndrome was analyzed for superantigen-carrying prophages, revealing phi149, which encodes superantigen SSA. Sequence analysis of the att-L proximal region of phi149 showed that the phage had a mosaic nature. Remarkably, we successfully obtained lysogenic conversion of GAS clinical isola...

The pharmacokinetics of apremilast and its major metabolite M12 were evaluated in subjects with varying degrees of renal impairment. Men and women with renal impairment (estimated glomerular filtration rate, 60-89 mL/min [mild, n = 8], 30-59 mL/min [moderate, n = 8], or <30 mL/min [severe, n = 8]) or demographically healthy matched (control) subjects (n = 24) received a single oral dose of apre...

Given that the FcgammaRIIIa receptor 158V allotype displays a higher affinity for human immunoglobulin G1 and increased antibody-dependent cellular cytotoxicity, the aim of this study was to determine the influence of that FCGR3A polymorphism on the therapeutic response to rituximab, an anti-CD20 humanized immunoglobulin G1 increasingly used in the treatment of non-Hodgkin lymphomas. The FCGR3A...

BACKGROUND AND OBJECTIVES In the first months after successful kidney transplantation, hypophosphatemia and renal phosphorus wasting are common and related to inappropriately high parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) levels. Little is known about the long-term natural history of renal phosphorus homeostasis in renal transplant recipients. DESIGN, SETTING, PARTICI...

In this letter we study the specific sensitivity and constraints to soft breaking Z2 parameter m12 of Two Higgs Doublet Model (2HDM). is considered here as an input model together with masses bosons, mh, mH, mA, mH±, ratio two vacuum expectation values, tan⁡β, cos⁡(β−α), α β mixing angles CP-even CP-odd sector, respectively. We explore in particular decays lightest boson h photons, assuming: 1)...

Epidemiological studies have proposed an association between group A streptococci (GAS) bearing a particular M serological type and pathologic conditions such as streptococcal toxic shock syndrome (STSS). M1 and M3 GAS are isolated from STSS cases more frequently, whereas M4 and M12 GAS are isolated from non-STSS cases more frequently. To investigate whether there is any difference contributing...

The high temperature form of melanophlogite, 46 Si02. 6M14 .2M12(M12=CH4, N2; M14=C02, N2), is cubic with space group Pm3n and a = 13.436(3) A at 200°C. The mineral is isostructural with the cubic gas hydrates of type I. Structure refinement with 667 independent reflections led to a weighted Rw = 0.040. Corner-sharing [Si04] tetrahedra form a 3dimensional framework which contains two types of c...