Little is known about the physiological roles of the M5 muscarinic receptor, the last member of the muscarinic receptor family (M1-M5) to be cloned. In the brain, the M5 receptor subtype is preferentially expressed by dopaminergic neurons of the substantia nigra and the ventral tegmental area. Dopaminergic neurons located in the ventral tegmental area are known to play important roles in mediat...

A single-site mutant (M5) of native urokinase plasminogen activator (prouPA) induces effective thrombolysis in dogs with venous or arterial thrombosis with a reduction in bleeding complications compared to tPA. This effect, related to inhibition of two-chain M5 (tcM5) by plasma C1-inhibitor (C1I), thereby preventing non-specific plasmin generation, was augmented by the addition of exogenous C1I...

Goldberg's International Personality Item Pool (IPIP; Goldberg, 1999) provides researchers with public-domain, free-access personality measurement scales that are proxies of well-established published scales. One of the more commonly used IPIP sets employs 50 items to measure the 5 broad domains of the 5-factor model, with 10 items per factor. The M5-50 (McCord, 2002) is a specific ordering and...

The model tree algorithm of M5 is integrated with the multiple linear regression technique called modified stepwise (MSR), resulting in a new method for modeling complex civil engineering problems. We purposefully chose artificial neural networks (ANN) comparison against proposed “M5+MSR” because they fall at two ends interpretability spectrum machine learning. This research addresses critical ...

capacity of garden productions in iran is such that is accounted as a country that produces thirteen garden products in the world but despite excellent condition in iran for producing garden products, natural disasters damage production of fruits in the country therefore farmers incur a loss. pistachio tree has been in danger of destruction and dryness. thus, in order to reduce loss incurred on...

Of the five muscarinic receptor subtypes, the M5 receptor is the only one detectable in midbrain dopaminergic neurons, making it an attractive potential therapeutic target for treating disorders in which dopaminergic signaling is disrupted. However, developing an understanding of the role of M5 in regulating midbrain dopamine neuron function has been hampered by a lack of subtype-selective comp...

Abstract In this research, an M5 model tree is employed for the prediction of removal efficiency azithromycin antibiotics by multi-wall carbon nanotubes (MWCNTs), based on experimental data sets from a laboratory column mode. The effect total flow time (0–260 min), influent rates (0.5, 1, and 1.5 mL min?1), bed depths (2, 4, 6 cm), initial concentrations (25, 50, 100 mg L?1), pHs 6, 8, 10) was ...