Despite decades of research, the question of how the mRNA splicing machinery precisely identifies short exonic islands within the vast intronic oceans remains to a large extent obscure. In this study, we analyzed Alu exonization events, aiming to understand the requirements for correct selection of exons. Comparison of exonizing Alus to their non-exonizing counterparts is informative because Al...

This paper outlines an approach for writing biological economic articles. There is a schism within economics between neoclassical and behavioral schools. Biology holds the promise of modern synthesis these apparently competing theories. Natural selection favors maximization analogous to sort assumed by economics. Behavior, however, produced specific physiologic machinery that sometimes produces...

Recent work in Optimality Theory (Prince and Smolensky 1993, McCarthy and Prince 1993, to appear) has suggested that phonological regularities can be explained without reference to phonological rules, strictly in terms of constraints on representational wellformedness. A unique aspect of Optimality Theory (OT) is that candidates are evaluated in parallel: there is no serial derivation. Given th...

Increasing evidence indicates that the transcriptional machinery can influence the efficiency of splicing as well as splice-site selection. Surprisingly, it has now been demonstrated that splicing components influence the efficiency of transcription. This mutual stimulation has important implications for the regulation of gene expression.

The Swedish 2008 Government’s Action Plan on eGovernment offers old wine (focussed on technology rather than on services; production-centred rather than needs-based) in old bottles (closed political systems rather than open infrastructure; no measurements and, consequently, no incentives for government agencies to change). This paper analyzes the Plan based on an Enterprise Architecture integra...

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An effective bearing fault diagnosis model based on machine learning is proposed in this study. The can separate into three stages: feature extraction, selection, and classification. In the stage of multiresolution analysis (MRA) fast Fourier transform (FFT) are applied to extract features from raw signal measured rotating machine. second stage, a powerful selection method utilized selection. n...

During the pre-construction phase of an investment project, a construction plan is usually prepared by building contractor. It contains financial plans, schedules, technical regulations with working procedures and proposals for deployment machinery work teams. These items are then optimised in order to save money, shorten time increase quality final while ensuring environmental safety standards...