Because to their magnetic properties, superparamagnetic iron oxide nanoparticles (SPIONs) might be considered as a good delivery vehicle after grafting of their surface with a therapeutical drug. On the other hand, drug encapsulation into liposomes allows protection of the agent against enzymatic degradation, reduces the dose and toxics effects; however, a selective and controlled release of th...

BACKGROUND The next generation magnetic nanoparticles (MNPs) with theranostic applications have attracted significant attention and will greatly improve nanomedicine in cancer therapeutics. Such novel MNP formulations must have ultra-low particle size, high inherent magnetic properties, effective imaging, drug targeting, and drug delivery properties. To achieve these characteristic properties, ...

Development of microspheres is a promising technology for controlled release and drug targeting. Various types such as bio-adhesive, magnetic, floating, radioactive polymeric are developed various purposes. Microspheres occupied central place in novel delivery. There departments medicine like cancer, pulmonary, cardiology, radiology, gynecology, oncology etc., where numerous drugs used delivere...

Despite significant advances in highly active antiretroviral therapy (HAART), the prevalence of neuroAIDS remains high. This is mainly attributed to inability of antiretroviral therapy (ART) to cross the blood-brain barrier (BBB), thus resulting in insufficient drug concentration within the brain. Therefore, development of an active drug targeting system is an attractive strategy to increase th...

Introduction: Graphene oxide (GO) sheets are carbon-networking nanomaterials offering excellent potential for drug delivery platforms due to hydrophobic interactions and high drug-loading efficiency. Superparamagnetic iron oxide nanoparticles can be used in certain applications such as cell labeling, drug delivery, targeting, magnetic resonance imaging and hyperthermia. Due t...

One of the several ways of enhancing the solubility of poorly soluble drugs is liposomes formulations. Research on liposomes formulations has progressed from that of conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Thermosensitive liposomes are also a pro...

Magnetic drug targeting (MDT) therapy is usually controlled through the magnetic field produced by a permanent magnet; the solution proposed and assessed here considers a planar spiral coil (PSC) or a system of such coils, as an equally effective magnetic field source. The PSC may be designed to provide proper configurations of the magnetic field gradients, required for the generation of high m...

PURPOSE A physics-based model of a general magnetic drug targeting (MDT) system was developed with the goal of realizing the practical limitations of MDT when electromagnets are the source of the magnetic field. METHODS The simulation tracks magnetic particles subject to gravity, drag force, magnetic force, and hydrodynamic lift in specified flow fields and external magnetic field distributio...

Controlled drug delivery systems (DDS) have several advantages compared to the traditional forms of drugs. A drug is transported to the place of action, hence, its influence on vital tissues and undesirable side effects can be minimized. Accumulation of therapeutic compounds in the target site increases and, consequently, the required doses of drugs are lower. This modern form of therapy is esp...

in the 1960s, discovery of pleasure system (defined as reward system) in the brain that may underlie drug reward and addiction encouraged many scientists to investigate the mechanisms by which drug abuse affects central nervous system function. in this regard, investigators developed several drugs targeting the brain reward system for drug dependence therapy. however, no positive results obtain...