MRI workers are occupationally exposed to static and time-varying gradient magnetic fields.  While the 24-hour time-averaged exposure to static magnetic fields is about a few mT, the maximum static field strength can be as high as 500 mT during patient setup. Over the past several years, our laboratory has performed extensive experiments on the health effects of exposure of animal models and h...

The canonical problem of designing the complex excitations feeding an array such to ensure a desired field intensity distribution inside given region interest, while keeping it under control in some other regions, is addressed. To this end, auxiliary physics inspired model for induced total proposed, whose off-line analysis allows simplified approach understand convenient and non-convenient int...

We present a proof of concept on the use of thermomagnetic polymer films (TMFs) as heating devices for magnetic hyperthermia in vitro. The TMFs were prepared through spray assisted layer-bylayer assembly of polysaccharides and magnetic iron oxide nanoparticles, yielding an alternate magnetic-polymer multilayer structure. By applying a remote alternating magnetic field (AMF) (f = 180 kHz; H = 35...

BACKGROUND Children undergoing magnetic resonance imaging (MRI) under sedation are at risk of hypo- or hyperthermia. The effect of brain MRI at differing magnetic field strengths on body core temperature in sedated infants and young children has not been reported previously. METHODS Two groups of 38 infants and children (aged 1 month to 6 yr 5 months) underwent brain MRI for different indicat...

cerebral palsy is the most common chronic motor disorder of childhood, that affecting approximately 3 infants per 1000 live-births. the risk of brain injuries that potentially cause cerebral palsy has amplified with increasing in survival rates for preterm infants. in addition cerebral palsy has a huge economic impact, to immeasurable health, social, and psychological problems that affected chi...

BACKGROUND Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. OBJECTIVE To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. METHODS An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The...

As the development of diagnostic/therapeutic (and combined: theranostic) nanomedicine grows, smart drug-delivery vehicles become ever more critical. Currently therapies consist of drugs tethered to, or encapsulated within nanoparticles or vesicles. There is growing interest in functionalising them with magnetic nanoparticles (MNPs) to target the therapeutics by localising them using magnetic fi...

Magnetotactic bacteria belong to a group of bacteria that synthesize iron oxide nanoparticles covered by biological material that are called magnetosomes. These bacteria use the magnetosomes as a compass to navigate in the direction of the earth's magnetic field. This compass helps the bacteria to find the optimum conditions for their growth and survival. Here, we review several medical applica...

The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to their broad clinical application. Here we develop a magnetic nucleic acid delivery system composed of iron oxide nanoparticles and cationic lipid-like materials termed lipidoids. Coated nanoparticles are capable of delivering DNA and siRNA to cells in culture. The mean hydrodynamic size of these nano...

Magnetic-nanoparticle-mediated intracellular hyperthermia has the potential to achieve localized tumor heating without any side effects. The technique consists of targeting magnetic nanoparticles to tumor tissue followed by application of an external alternating magnetic field that induces heat through Néel relaxation loss of the magnetic nanoparticles. The temperature in tumor tissue is increa...