Background: The use of doxorubicin in chemotherapy has been associated with cardiotoxicity and heart failure. Physical exercise produces favorable morphofunctional adaptations the cardiovascular system may reverse cardiac dysfunction patients undergoing chemotherapy. Objective: To assess effects physical training on myocardial structure, function, tolerance Wistar rats initiated after onset car...

Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats grouped into 3 (n=15/group): Group 1- Control, 2- Diabetes, 3- Postprandial hyperglycemia. The 15 per group sub-grouped of 5 each. Each sub-group determined gastric emptying...

The present study investigated the nephrotoxic effect of aqueous extract Dialium guineense stem bark in normal Wistar albino rats. Thirty-five male rats were used. Graded doses ranging from 200 to 5000 mg/kg body weight, bwt, administered test daily for twenty-eight days. control received distilled water. Thereafter plasma levels creatinine, urea, electrolytes and urease activity determined. Th...

The aim of our study was to evaluate the effects cannabinoids and serotonergic system on nociception in intact rats after heat stress. Cannabinoid receptor type 1 (CB1) 5-hydroxytryptamine (5НТ 1А ) agonists antagonists have been administered according different experimental designs (alone combinations) male Wistar rats, as well animals subjected one hour Pain perception has evaluated by Paw pr...

In order to reproduce chronic cerebral hypoperfusion as it occurs in human aging and Alzheimer's disease, we introduced permanent, bilateral occlusion of the common carotid arteries (BCCAO) in rats (Farkas et al, 2007). Here, we induced BCCAO in two different rat strains in order to determine whether there was a strain difference in the pathogenic response to BCCAO. Male Wistar and Sprague-Dawl...

AIMS We investigated the effects of hypertension and acute blood pressure changes on rats' vesicovascular reflexes (VVRs). MAIN METHODS Twelve-week-old male Wistar rats and spontaneously hypertensive rats (SHRs) were anesthetized with urethane, and underwent real-time cystometry and blood pressure monitoring. The SHRs were administered nifedipine or valsartan intravenously. The Wistar rats we...

The results of modeling acute myocardial infarction on 20 male Wistar rats aged 24 months are presented. Ischemic effect is carried out by local injection 1.5% sclerosant ethoxysclerol (0.25 ml) into the thickness myocardium under general anesthesia using non-traumatic needle with silicone coating, which allows to simulate minimal invasive animal's body, trauma, little duration intervention, lo...