Rat strains differ strikingly in susceptibility to cancer. The rat strain WKY is highly resistant, while the SPRDCu3 strain is susceptible to chemically-induced mammary cancer. We previously showed that two chromosome regions (from chromosomes 5 and 18) contain quantitative trait loci (QTLs) controlling mammary cancer susceptibility. Here we tested the hypothesis that mammary cancer resistance ...

In human mammary cancer cells, pro-cathepsin D (pro-Cath-D) is induced by estrogens and 50% of it is secreted. To determine whether its secretion is characteristic of mammary cells or transformed cells, we compared its production, processing, and glycosylation in primary cul tures of normal mammary epithelial cells to those found in breast cancer cell lines. The cytosolic concentration of total...

Folic acid supplementation may prevent the development of cancer in normal tissues but may promote the progression of established (pre)neoplastic lesions. However, whether or not folic acid supplementation can promote the progression of established (pre)neoplastic mammary lesions is unknown. This is a critically important issue because breast cancer patients and survivors in North America are l...

In human mammary cancer cells, pro-cathepsin D (pro-Cath-D) is induced by estrogens and 50% of it is secreted. To determine whether its secretion is characteristic of mammary cells or transformed cells, we compared its production, processing, and glycosylation in primary cultures of normal mammary epithelial cells to those found in breast cancer cell lines. The cytosolic concentration of total ...

GPR109A, a G-protein-coupled receptor, is activated by niacin and butyrate. Upon activation in colonocytes, GPR109A potentiates anti-inflammatory pathways, induces apoptosis, and protects against inflammation-induced colon cancer. In contrast, GPR109A activation in keratinocytes induces flushing by activation of Cox-2-dependent inflammatory signaling, and the receptor expression is upregulated ...

Background/Aim: Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics mammary carcinomas induced by neutrons. Materials and Methods: Mammary obtained female Sprague-Dawley rats irradiated at 7 weeks age with 0.97 Gy neutrons or 4 ?-rays non-irradiated were classified into luminal non-luminal subtypes immunohistochemistry. Their mutational land...

When treated with 17β-estradiol, female ACI rats (Rattus norvegicus) rapidly develop mammary cancers that share multiple phenotypes with luminal breast cancers. Seven distinct quantitative trait loci that harbor genetic determinants of susceptibility to 17β-estradiol-induced mammary cancer have been mapped in reciprocal intercrosses between susceptible ACI rats and resistant Brown Norway (BN) r...

Abstract Background Due to the high variability of incidence and prevalence intra-mammary lymph nodes (IMLNs), they might be overlooked during clinical radiological examinations. Properly characterizing pathological IMLNs detecting factors that influence their in different stages breast cancer aid proper therapeutic decision-making could possible prognostic value. Methods Medical records were r...

Amplified in breast cancer 1 (AIB1; steroid receptor coactivator-3, p/CIP, RAC3, ACTR, TRAM-1, or NCoA-3) is a transcriptional coactivator for nuclear receptors and certain other transcription factors and is a newly defined oncogene overexpressed in human breast cancer. Although the role and molecular mechanism of AIB1 in normal physiology and in breast cancer are currently under intensive inve...